Lazertinib

Product Name: Lazertinib
CAS No.: 1903008-80-9
Chemical Name: Lazertinib
Synonyms: GNS1480;CS-2767;YH25448;GNS-1480;Lazertinib;Lazertinib (YH25448);Abituzumab intermediate;Lazertinib, 10 mM in DMSO;Lazertinib(YH25448,GNS-1480);YH 25448;YH25448;GNS-1480;GNS1480
CBNumber: CB84632533
Molecular Formula: C30H34N8O3
Formula Weight: 554.64
MOL File: 1903008-80-9.mol

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Lazertinib Property

Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:6.5(Max Conc. mg/mL);11.72(Max Conc. mM)
form: A solid
pka: 12.39±0.70(Predicted)
color: Light yellow to yellow
InChIKey: RRMJMHOQSALEJJ-UHFFFAOYSA-N
SMILES: C(NC1=CC(NC2=NC=CC(N3C=C(CN(C)C)C(C4=CC=CC=C4)=N3)=N2)=C(OC)C=C1N1CCOCC1)(=O)C=C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29670
Product name: Lazertinib
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 29670
Product name: Lazertinib
Packaging: 50mg
Price: $480
Updated: 2024/03/01

Cayman Chemical

Product number: 29670
Product name: Lazertinib
Packaging: 10mg
Price: $145
Updated: 2024/03/01

Cayman Chemical

Product number: 29670
Product name: Lazertinib
Packaging: 25mg
Price: $265
Updated: 2024/03/01

TRC

Product number: L215260
Product name: Lazertinib
Packaging: 250mg
Price: $1890
Updated: 2021/12/16

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Lazertinib Chemical Properties,Usage,Production

Description

Lazertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) that is able to penetrate the central nervous system (CNS) and has been approved in South Korea for the treatment of patients with EGFR T790M mutation-positive non-small cell lung cancer (NSCLC) who have been previously treated with EGFR-TKIs.

Uses

Lazertinib is used in the preparation of heteroaryl pyrimidinylamine compounds for modulating EGFR mutant kinase activities. EGFR tyrosine-kinase inhibitor.

Synthesis

The construction of the second building block of lazertinib (22.7) began with a SNAr reaction between the aryl fluoride 22.4 and morpholine. The aniline nitrogen atom in 22.4 was formylated prior to nitro reduction. The newly formed aniline (22.5) underwent acylation with 3-chloropropionyl chloride (22.6) followed by a base-catalyzed elimination to afford the acrylate 22.7. Deprotonation of the N-formanilide prior to treatment with methyl sulfone 22.3 and subsequent exposure to aqueous sodium hydroxide promoted the binding of the 22.3 and 22.7 fragments and the simultaneous removal of the N-formyl group to afford the aminopyrimidine acrylate 22.8. Finally, a dimethylamino group was introduced via a STAB-H-mediated reductive amination to afford lazertinib (22) in high yield.

IC 50

EGFR^T790M

Lazertinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Lazertinib Suppliers

China 96 India 1 United States 6 Global 103

Jinan shenlikang chemical technology co. LTD

Tel: 0531-86092839 13153040268
Fax: QQ：2425815073
Email: 2425815073@qq.com
Country: China
ProdList: 265
Advantage: 58

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 18971495150;
Email: sales@sun-shinechem.com
Country: China
ProdList: 1077
Advantage: 64

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15727060112
Email: yutianchun2007@126.com
Country: China
ProdList: 9814
Advantage: 58

CAREBIO PHARMA

Tel: 18501057619 18501057619;
Email: jackyfan@rebornpharma.com
Country: China
ProdList: 265
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4768
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2991
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Shanghai Chaolan Chemical Technology Center

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Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
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Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 10410
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
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1903008-80-9, LazertinibRelated Search:

CS-2767

Lazertinib(YH25448,GNS-1480)

YH 25448;YH25448;GNS-1480;GNS1480

GNS1480

GNS-1480

LAZERTINIB; YH-25448; YH 25448; YH25448; GNS-1480; GNS 1480; GNS1480.

Lazertinib

YH25448

Lazertinib (YH25448)

2-Propenamide, N-[5-[[4-[4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl]-2-pyrimidinyl]amino]-4-methoxy-2-(4-morpholinyl)phenyl]-

Abituzumab intermediate

ErbB-1,YH 25448,GNS1480,Lazertinib,EGFR,Inhibitor,YH-25448,Epidermal growth factor receptor,GNS 1480,HER1,inhibit

N-(5-((4-(4-((Dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)amino)-4-methoxy-2-morpholinophenyl)acrylamide

Lazertinib, 10 mM in DMSO

N-{5-[(4-{4-[(dimethylamino)methyl]-3-phenyl-1H-pyrazol-1-yl}pyrimidin-2-yl)amino]-4-methoxy-2-(morpholin-4-yl)phenyl}prop-2-enamide

1903008-80-9

C30H34N8O3

APIs