2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid

Product Name
2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid
CAS No.
2102196-57-4
Chemical Name
2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid
Synonyms
FAA1 agonist-1;GPR40 agonist 4;GPR-40 agonist 4,GPR40 agonist 4;2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfony...;2-[4-({2'-chloro-[1,1'-biphenyl]-3-yl}methoxy)benzenesulfonyl]acetic acid;2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid;Acetic acid, 2-?[[4-?[(2'-?chloro[1,?1'-?biphenyl]?-?3-?yl)?methoxy]?phenyl]?sulfonyl]?-
CBNumber
CB84635367
Molecular Formula
C21H17ClO5S
Formula Weight
416.87
MOL File
2102196-57-4.mol
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2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid Property

Melting point:
121 - 123°C
Boiling point:
644.4±55.0 °C(Predicted)
Density 
1.370±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly, Sonicated), Methanol (Slightly)
form 
Solid
pka
2.58±0.10(Predicted)
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C327230
Product name
2-[[4-[(2''-Chloro[1,1''-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]aceticAcid
Packaging
1mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-0023823
Product name
GPR40agonist4
Purity
98.69%
Packaging
5mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-0023823
Product name
GPR40agonist4
Purity
98.69%
Packaging
10mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-0023823
Product name
GPR40agonist4
Purity
98.69%
Packaging
25mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0023823
Product name
GPR40agonist4
Purity
98.69%
Packaging
50mg
Price
$550
Updated
2021/12/16
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2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid Chemical Properties,Usage,Production

Uses

2-[[4-[(2''-Chloro[1,1''-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic Acid, is a potent free fatty acid receptor 1 (FFA1/ GPR40) agonist with a pEC50 of 7.54.

in vivo

Single oral administration of GPR40 agonist 4 (compound 20) robustly reduces the plasma glucose excursion and enhances insulin secretion during an oral glucose tolerance test (OGTT) in a dose-dependent manner from 1 to 10 mg/kg when GPR40 agonist 4 is dosed 60 min prior to the oral glucose challenge. The area under the curve of blood glucose (AUC0-120min) and blood insulin (AUC0-120min) reveal that the minimum effective dose of GPR40 agonist 4 is 3 mg/kg. The hyperglycemia state is also markedly improved in GPR40 agonist 4 (20 mg/kg) treated group[1].

2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid Suppliers

China 30 United States 2 Global 32
Shanghai Lollane Biological Technology Co.,Ltd.
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2102196-57-4, 2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acidRelated Search:


  • 2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfonyl]acetic acid
  • FAA1 agonist-1
  • Acetic acid, 2-?[[4-?[(2'-?chloro[1,?1'-?biphenyl]?-?3-?yl)?methoxy]?phenyl]?sulfonyl]?-
  • GPR40 agonist 4
  • 2-[[4-[(2'-Chloro[1,1'-biphenyl]-3-yl)methoxy]phenyl]sulfony...
  • GPR-40 agonist 4,GPR40 agonist 4
  • 2-[4-({2'-chloro-[1,1'-biphenyl]-3-yl}methoxy)benzenesulfonyl]acetic acid
  • 2102196-57-4
  • C21H17ClO5S