6.beta.-Naltrexol-d3

Product Name: 6.beta.-Naltrexol-d3
CAS No.: 1435727-11-9
Chemical Name: 6.beta.-Naltrexol-d3
Synonyms: 6β-Naltrexol-d3;6.beta.-Naltrexol-d3;6β-Naltrexol-d3 (CRM);6β-Naltrexol-d3 (CRM);6.beta.-Naltrexol-d3 (CRM);6β-Naltrexol-D₃ solution;(5α,6β)-17-(cyclopropylmethyl)-4,5-epoxy-d3-morphinan-3,6,14-triol
CBNumber: CB84665856
Molecular Formula: C20H22D3NO4
Formula Weight: 346.435285334
MOL File: 1435727-11-9.mol

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6.beta.-Naltrexol-d3 Property

storage temp.: -20°C
form: A neat solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18350
Product name: 6β-Naltrexol-d3
Purity: ≥98%
Packaging: 500μg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 18350
Product name: 6β-Naltrexol-d3
Purity: ≥98%
Packaging: 1mg
Price: $230
Updated: 2024/03/01

Cayman Chemical

Product number: 20396
Product name: 6β-Naltrexol-d3 (CRM)
Packaging: 100μg
Price: $238
Updated: 2024/03/01

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6.beta.-Naltrexol-d3 Chemical Properties,Usage,Production

Description

6β-Naltrexol-d₃ (Item No. 18350) is an analytical reference material intended for use as an internal standard for the quantification of 6β-naltrexol by GC- or LC-MS. 6β-Naltrexol is the major metabolite of naltrexone (Item Nos. ISO60192 | 15520). It is a neutral μ-opioid receptor antagonist (K_i = 94 pM). This product is intended for research and forensic applications.

Uses

6β-Naltrexol-d3 (6β-Hydroxynaltrexone-d3) is deuterium labeled 6β-Naltrexol. 6β-Naltrexol (6β-Hydroxynaltrexone), the primary metabolite of Naltrexone, is a peripherally selective opioid antagonist. 6β-Naltrexol selectively inhibits gastrointestinal opioid effects in human subjects and inhibits Morphine-induced slowing of gastrointestinal transit[1][2].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Cone EJ, et al. Biosynthesis, isolation, and identification of 6-beta-hydroxynaltrexone, a major human metabolite of naltrexone. J Pharm Sci. 1975 Apr;64(4):618-21. DOI:10.1002/jps.2600640409
[3] Yancey-Wrona J, et al. 6β-naltrexol, a peripherally selective opioid antagonist that inhibits morphine-induced slowing of gastrointestinal transit: an exploratory study. Pain Med. 2011 Dec;12(12):1727-37. DOI:10.1111/j.1526-4637.2011.01279.x

6.beta.-Naltrexol-d3 Preparation Products And Raw materials

Raw materials

Preparation Products

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6.beta.-Naltrexol-d3 Suppliers

China 5 United States 1 Global 6

TOSUN PHARM

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Cayman Chemical Company

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Merck KGaA

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Henan Inokai New Materials Co., Ltd

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1435727-11-9, 6.beta.-Naltrexol-d3Related Search:

6.beta.-Naltrexol-d3

6.beta.-Naltrexol-d3 (CRM)

6β-Naltrexol-d3 (CRM)

(5α,6β)-17-(cyclopropylmethyl)-4,5-epoxy-d3-morphinan-3,6,14-triol

6β-Naltrexol-d3

6β-Naltrexol-D<sub>3</sub> solution

6β-Naltrexol-d3 (CRM)

1435727-11-9