AA9
- Product Name
- AA9
- CAS No.
- 1467047-25-1
- Chemical Name
- AA9
- Synonyms
- SRS11-92;SRS11-92, 10 mM in DMSO;Ethyl 3-(benzylamino)-4-(cyclohexylamino)benzoate;Benzoic acid, 4-(cyclohexylamino)-3-[(phenylmethyl)amino]-, ethyl ester;HT-1080,FRDA,Friedreich,Inhibitor,cell death,ataxia,SRS-11-92,SRS1192,Ferroptosis,inhibit,SRS11 92,SRS11-92
- CBNumber
- CB84665937
- Molecular Formula
- C22H28N2O2
- Formula Weight
- 352.47
- MOL File
- 1467047-25-1.mol
AA9 Property
- Boiling point:
- 523.7±45.0 °C(Predicted)
- Density
- 1.152±0.06 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml
- form
- A crystalline solid
- pka
- 5.48±0.20(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 25689
- Product name
- AA9
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 25689
- Product name
- AA9
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 25689
- Product name
- AA9
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- 25689
- Product name
- AA9
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $533
- Updated
- 2024/03/01
- Product number
- 5392DV
- Product name
- Ethyl3-(benzylamino)-4-(cyclohexylamino)benzoate
- Packaging
- 25mg
- Price
- $691
- Updated
- 2021/12/16
AA9 Chemical Properties,Usage,Production
Definition
ChEBI: SRS11-92 is an ethyl ester resulting from the formal condensation of the carboxy group of 3-(benzylamino)-4-(cyclohexylamino)benzoic acid with ethanol. It is a potent inhibitor of ferroptosis induced by erastin in HT-1080 human fibrosarcoma cells (EC50 = 6 nM). It has a role as a ferroptosis inhibitor. It is a substituted aniline, an ethyl ester, a secondary amino compound and a diamine. It is functionally related to a ferrostatin-1.
Biological Activity
SRS11-92 is a cell penetrant and potent inhibitor of ferroptosis th at attenuates the cell death associated with frataxin knockdown in healthy human fibroblasts. SRS11-92 protects against cell death in in a brain slice model of Huntington′s disease, an oligodendrocyte model of periventricular leukomalacia, and in isolated kidney proximal tubules model of kidney disfunction.
AA9 Preparation Products And Raw materials
Raw materials
Preparation Products
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