AA9

Product Name: AA9
CAS No.: 1467047-25-1
Chemical Name: AA9
Synonyms: SRS11-92;SRS11-92, 10 mM in DMSO;Ethyl 3-(benzylamino)-4-(cyclohexylamino)benzoate;Benzoic acid, 4-(cyclohexylamino)-3-[(phenylmethyl)amino]-, ethyl ester;HT-1080,FRDA,Friedreich,Inhibitor,cell death,ataxia,SRS-11-92,SRS1192,Ferroptosis,inhibit,SRS11 92,SRS11-92
CBNumber: CB84665937
Molecular Formula: C22H28N2O2
Formula Weight: 352.47
MOL File: 1467047-25-1.mol

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AA9 Property

Boiling point:: 523.7±45.0 °C(Predicted)
Density: 1.152±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml
form: A crystalline solid
pka: 5.48±0.20(Predicted)
color: White to off-white
InChIKey: VHQAJFNLPQULSV-UHFFFAOYSA-N
SMILES: N(C3CCCCC3)c1c(cc(cc1)C(=O)OCC)NCc2ccccc2

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25689
Product name: AA9
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 25689
Product name: AA9
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 25689
Product name: AA9
Purity: ≥98%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

Cayman Chemical

Product number: 25689
Product name: AA9
Purity: ≥98%
Packaging: 25mg
Price: $533
Updated: 2024/03/01

AK Scientific

Product number: 5392DV
Product name: Ethyl3-(benzylamino)-4-(cyclohexylamino)benzoate
Packaging: 25mg
Price: $691
Updated: 2021/12/16

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AA9 Chemical Properties,Usage,Production

Uses

SRS11-92, a Ferrostatin-1 (Fer-1) analogue, is a potent ferroptosis inhibitor. SRS11-92 inhibits ferroptotic cell death induced by Erastin in HT-1080 human fibrosarcoma cells (EC50=6 nM)[1].

Definition

ChEBI: SRS11-92 is an ethyl ester resulting from the formal condensation of the carboxy group of 3-(benzylamino)-4-(cyclohexylamino)benzoic acid with ethanol. It is a potent inhibitor of ferroptosis induced by erastin in HT-1080 human fibrosarcoma cells (EC50 = 6 nM). It has a role as a ferroptosis inhibitor. It is a substituted aniline, an ethyl ester, a secondary amino compound and a diamine. It is functionally related to a ferrostatin-1.

Biological Activity

SRS11-92 is a cell penetrant and potent inhibitor of ferroptosis th at attenuates the cell death associated with frataxin knockdown in healthy human fibroblasts. SRS11-92 protects against cell death in in a brain slice model of Huntington′s disease, an oligodendrocyte model of periventricular leukomalacia, and in isolated kidney proximal tubules model of kidney disfunction.

in vivo

SRS11-92, used at 500 nM, is efficacious in protecting human and mouse cellular models of Friedreich ataxia (FRDA) treated with ferric ammonium citrate (FAC) and an inhibitor of glutathione synthesis (BSO), whereas caspase-3 inhibitors fail to show significant biological activity^[2].

References

[1] Skouta R, et al. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc. 2014;136(12):4551-4556. DOI:10.1021/ja411006a
[2] Cotticelli MG, et al. Ferroptosis as a Novel Therapeutic Target for Friedreich's Ataxia. J Pharmacol Exp Ther. 2019;369(1):47-54. DOI:10.1124/jpet.118.252759

AA9 Preparation Products And Raw materials

Raw materials

Preparation Products

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AA9 Suppliers

China 30 United States 5 Global 35

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
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Shanghai YuanYe Biotechnology Co., Ltd.

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Tianjin Kailiqi Biotechnology Co., Ltd.

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ShangHai Biochempartner Co.,Ltd

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Shanghai Chaolan Chemical Technology Center

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Shanghai SuperLan Chemcial Technique Centre

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Shanghai Hongye Biotechnology Co. Ltd

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TargetMol Chemicals Inc.

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InvivoChem

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HANGZHOU CLAP TECHNOLOGY CO.,LTD

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1467047-25-1, AA9Related Search:

SRS11-92

Benzoic acid, 4-(cyclohexylamino)-3-[(phenylmethyl)amino]-, ethyl ester

HT-1080,FRDA,Friedreich,Inhibitor,cell death,ataxia,SRS-11-92,SRS1192,Ferroptosis,inhibit,SRS11 92,SRS11-92

Ethyl 3-(benzylamino)-4-(cyclohexylamino)benzoate

SRS11-92, 10 mM in DMSO

1467047-25-1