C18 Ceramide-d3 (d18:1/18:0-d3)
- Product Name
- C18 Ceramide-d3 (d18:1/18:0-d3)
- CAS No.
- 2011762-82-4
- Chemical Name
- C18 Ceramide-d3 (d18:1/18:0-d3)
- Synonyms
- C18 Ceramide-d3 (d18:1/18:0-d3);N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl-d3]-octadecanamide
- CBNumber
- CB84666080
- Molecular Formula
- C36H71NO3
- Formula Weight
- 565.97
- MOL File
- 2011762-82-4.mol
C18 Ceramide-d3 (d18:1/18:0-d3) Property
- storage temp.
- Store at -20°C
- solubility
- Chloroform: Soluble,DMF: Soluble,Ethanol: Warmed
- form
- A solid
N-Bromosuccinimide Price
- Product number
- 24396
- Product name
- C18 Ceramide-d3 (d18:1/18:0-d3)
- Purity
- ≥99% deuterated forms (d1-d3); ≤1% d0
- Packaging
- 1mg
- Price
- $426
- Updated
- 2024/03/01
- Product number
- 1487EN
- Product name
- 18,18,18-Trideuterio-N-[(E,2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl]octadecanamide
- Packaging
- 1mg
- Price
- $826
- Updated
- 2021/12/16
C18 Ceramide-d3 (d18:1/18:0-d3) Chemical Properties,Usage,Production
Biological Activity
C18 Ceramide-d3 (d18:1/18:0) is intended for use as an internal standard for the quantification of C18 Ceramide (d18:1/18:0) by GC- or LC-MS. C18 Ceramide is an endogenous bioactive sphingolipid. It is the primary short-chain ceramide found in brain tissue whose synthesis is regulated by longevity-assurance homologue 1 (Lass1) in mice.1 Increased expression of C18 ceramide reduces cell growth in UM-SCC-22A squamous cell carcinoma cells.2 It is selectively downregulated in 32 human head and neck squamous cell carcinoma tumor tissues as compared to non-squamous tumor tissues. C18 Ceramide concentration is significantly higher in muscle tissue of type 2 diabetic patients compared with non-diabetic patients and is positively correlated to body mass index and inversely related to insulin sensitivity.3 [Matreya, LLC. Catalog No. 2201]
References
1.Mizutani, Y., Kihara, A., and Igarashi, Y.Mammalian Lass6 and its related family members regulate synthesis of specific ceramidesBiochem J.390(Pt. 1)263-271(2005) 2.Koybasi, S., Senkal, C.E., Sundararaj, K., et al.Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomasJ. Biol. Chem.279(43)44311-44319(2004) 3.Bergman, B.C., Brozinick, J.T., Strauss, A., et al.Muscle sphingolipids during rest and exercise: A C18:0 signature for insulin resistance in humansDiabetologia59(3)785-791(2016)
C18 Ceramide-d3 (d18:1/18:0-d3) Preparation Products And Raw materials
Raw materials
Preparation Products
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