Ac-DNLD-AMC
- Product Name
- Ac-DNLD-AMC
- CAS No.
- 958001-92-8
- Chemical Name
- Ac-DNLD-AMC
- Synonyms
- Ac-DNLD-AMC;Ac-Asp-Asn-Leu-Asp-MCA [Ac-DNLD-MCA] (5 mg vial);AC-DNLD-AMC;CASPASE-3 SUBSTRATE;AC-ASP-ASN-LEU-ASP-MCA;N-acetyl-L-α-aspartyl-L-asparaginyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-α-asparagine;L-α-Asparagine, N-acetyl-L-α-aspartyl-L-asparaginyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
- CBNumber
- CB84666116
- Molecular Formula
- C30H38N6O12
- Formula Weight
- 674.66
- MOL File
- 958001-92-8.mol
Ac-DNLD-AMC Property
- Boiling point:
- 1211.3±65.0 °C(Predicted)
- Density
- 1.402±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Formic Acid: 1 mg/ml
- form
- A lyophilized powder
- pka
- 4.09±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- 24566
- Product name
- Ac-DNLD-AMC
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 24566
- Product name
- Ac-DNLD-AMC
- Purity
- ≥95%
- Packaging
- 5 mg
- Price
- $162
- Updated
- 2024/03/01
- Product number
- 24566
- Product name
- Ac-DNLD-AMC
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $28
- Updated
- 2023/01/06
- Product number
- DC11359
- Product name
- Caspase-3Substrate
- Purity
- >98%
- Packaging
- 1g
- Price
- $3500
- Updated
- 2021/12/16
Ac-DNLD-AMC Chemical Properties,Usage,Production
Description
Ac-DNLD-AMC is a fluorogenic caspase-3 substrate. Upon enzymatic cleavage by caspase-3, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify caspase-3 activity. AMC displays excitation/emission maxima of 340-360 and 440-460 nm, respectively.
Uses
Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity[1][2].
References
[1] Kulikov AV, et al. Targeting mitochondria by α-tocopheryl succinate overcomes hypoxia-mediated tumor cell resistance to treatment. Cell Mol Life Sci. 2014 Jun;71(12):2325-33. DOI:10.1007/s00018-013-1489-8
[2] Yoshida K, et al. Caspase-independent cell death without generation of reactive oxygen species in irradiated MOLT-4 human leukemia cells. Cell Immunol. 2009;255(1-2):61-8. DOI:10.1016/j.cellimm.2008.10.006
Ac-DNLD-AMC Preparation Products And Raw materials
Raw materials
Preparation Products
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