BAY-678

Product Name: BAY-678
CAS No.: 675103-36-3
Chemical Name: BAY-678
Synonyms: BAY-678;BAY 678,BAY678;5-[(4R)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile;2-Pyridinecarbonitrile, 5-[(4R)-5-acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-
CBNumber: CB84666242
Molecular Formula: C20H15F3N4O2
Formula Weight: 400.35
MOL File: 675103-36-3.mol

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BAY-678 Property

Boiling point:: 623.9±55.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
pka: 9.35±0.70(Predicted)
form: powder
color: white to light brown
optical activity: [α]/D +21 to +29°, c = 0.5 in methanol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1563
Product name: BAY-678
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $108
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1563
Product name: BAY-678
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $435
Updated: 2024/03/01

Cayman Chemical

Product number: 18615
Product name: BAY-678
Purity: ≥98%
Packaging: 1mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 18615
Product name: BAY-678
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 18615
Product name: BAY-678
Purity: ≥98%
Packaging: 10mg
Price: $166
Updated: 2024/03/01

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BAY-678 Chemical Properties,Usage,Production

Uses

BAY 678, is a human neutrophil elastase (HNE) inhibitor with >2,000-fold selectivity for HNE over a panel of 21 other serine proteases.

Biological Activity

bay-678 is an orally active, potent and selective inhibitor of human neutrophil elastase (hne) [1][2].human neutrophil elastase (hne) is a member of the chymotrypsin-like family of serine proteases and is stored in the neutrophil cytoplasm. hne is a key protease for matrix degradation and high hne activity is occured in inflammatory diseases. so hne is a potential target for the treatment of pulmonary diseases such as acute lung injury (ali), acute respiratory distress syndrome (ards), chronic obstructive pulmonary disease (copd), bronchiectasis (be), and pulmonary hypertension (ph) [1].bay-678 is an orally active, potent and selective inhibitor of human neutrophil elastase (hne). bay-678 inhibited hne reversibly with ic50 value of 20 nm and ki value of 15 nm. bay-678 showed no inhibition against 21 related serine proteases, up to a concentration of 30 μm [1].in rats, bay-678 showed medium clearance with t1/2 of 1.3h [1].

Biochem/physiol Actions

BAY-678 is an orally available, highly potent and selective inhibitor of human neutrophil elastase (HNE). For full characterization details, please visit the BAY-678 probe summary on the Structural Genomics Consortium (SGC) website.BAY-677 is used as a negative control and is available from Sigma. To learn more about and purchase BAY-677, click here.To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc

storage

Store at -20°C

References

[1]. von nussbaum f, li vm, allerheiligen s, et al. freezing the bioactive conformation to boost potency: the identification of bay 85-8501, a selective and potent inhibitor of human neutrophil elastase for pulmonary diseases. chemmedchem. 2015 jul;10(7):1163-73.
[2]. von nussbaum f, li vm, meibom d, et al. potent and selective human neutrophil elastase inhibitors with novel equatorial ring topology: in vivo efficacy of the polar pyrimidopyridazine bay-8040 in a pulmonary arterial hypertension rat model. chemmedchem. 2016 jan 19;11(2):199-206.

BAY-678 Preparation Products And Raw materials

Raw materials

Preparation Products

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BAY-678 Suppliers

China 22 United Kingdom 1 United States 10 Global 33

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675103-36-3, BAY-678Related Search:

BAY-678

5-[(4R)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile

2-Pyridinecarbonitrile, 5-[(4R)-5-acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-

BAY 678,BAY678

675103-36-3