Resolvin D4
- Product Name
- Resolvin D4
- CAS No.
- 1025684-60-9
- Chemical Name
- Resolvin D4
- Synonyms
- Resolvin D4;6,8,10,13,15,19-Docosahexaenoic acid, 4,5,17-trihydroxy-, (4S,5R,6E,8E,10Z,13Z,15E,17S,19Z)-
- CBNumber
- CB84666282
- Molecular Formula
- C22H32O5
- Formula Weight
- 376.49
- MOL File
- 1025684-60-9.mol
Resolvin D4 Property
- Boiling point:
- 609.2±55.0 °C(Predicted)
- Density
- 1.101±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.5 mg/ml
- pka
- 4.50±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 13835
- Product name
- Resolvin D4
- Purity
- ≥95%
- Packaging
- 10μg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 13835
- Product name
- Resolvin D4
- Purity
- ≥95%
- Packaging
- 25μg
- Price
- $362
- Updated
- 2024/03/01
- Product number
- 13835
- Product name
- Resolvin D4
- Purity
- ≥95%
- Packaging
- 50μg
- Price
- $684
- Updated
- 2024/03/01
- Product number
- 13835
- Product name
- Resolvin D4
- Purity
- ≥95%
- Packaging
- 100μg
- Price
- $1199
- Updated
- 2024/03/01
Resolvin D4 Chemical Properties,Usage,Production
Uses
Resolvin D4 is a critical specialized proresolving mediator that limits NETosis in the formation of the clot, as well as regulating the rate of clot resolution.
Definition
ChEBI: Resolvin D4 is a member of the class of resolvins that is (6E,8E,10Z,13Z,15E,19Z)-docosahexaenoic acid carrying three hydroxy substituents at positions 4, 5 and 17 (the 4S,5R,17S-stereoisomer). It has a role as an anti-inflammatory agent and a human xenobiotic metabolite. It is a resolvin, a secondary allylic alcohol, a triol and a hydroxy polyunsaturated fatty acid.
in vivo
Resolvin D4 (RvD4, 10?ng/mouse) decreases percent of PMN, giving ~31% reduction at 4 hours[1].
Resolvin D4 (RvD4, 10?ng/mouse) modulates the severity of thrombo-inflammatory disease in vivo and improves thrombus resolution[2].
| Animal Model: | 6-8-week-old male FVB mice (a self-limited bacterial inoculation (105 c.f.u) into the dorsal pouch)[1]. |
| Dosage: | 200?ng/mouse (saline containing 0.01% EtOH). |
| Administration: | I.P.. |
| Result: | Gave lower PMN levels in the cavity in mice treated with RvD4. Significantly lowered bacterial counts when compared to vehicle control. Stopped leukocyte influx to the site of infection in the dorsal pouch cavity as well as the inflammation-initiating eicosanoids by reducing levels of PGD2 and LTB4. |
| Animal Model: | Thrombus-bearing mice[2]. |
| Dosage: | 3 μg. |
| Administration: | IV via tail vein injection on day 1 and day 4 after IVC stenosis. |
| Result: | Accelerated venous thrombus resolution in mice. |
Resolvin D4 Preparation Products And Raw materials
Raw materials
Preparation Products
Resolvin D4 Suppliers
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