C30(-hydroxy) Ceramide (d18:1/30:0)
- Product Name
- C30(-hydroxy) Ceramide (d18:1/30:0)
- CAS No.
- 457100-08-2
- Chemical Name
- C30(-hydroxy) Ceramide (d18:1/30:0)
- Synonyms
- C30(ω-hydroxy) Ceramide (d18:1/30:0);C30(-hydroxy) Ceramide (d18:1/30:0);30-Hydroxytriacontanoyl-D-erythro-sphingosine;30-hydroxy-N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-triacontanamide;Triacontanamide, 30-hydroxy-N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-
- CBNumber
- CB84666343
- Molecular Formula
- C48H95NO4
- Formula Weight
- 750.27
- MOL File
- 457100-08-2.mol
C30(-hydroxy) Ceramide (d18:1/30:0) Property
- Boiling point:
- 828.2±65.0 °C(Predicted)
- Density
- 0.922±0.06 g/cm3(Predicted)
- solubility
- Chloroform:Methanol (5:1): Soluble; DMF: Soluble; Ethanol: Heated
- form
- A solid
- pka
- 13.54±0.20(Predicted)
N-Bromosuccinimide Price
- Product number
- 22688
- Product name
- C30(ω-hydroxy) Ceramide (d18:1/30:0)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $572
- Updated
- 2024/03/01
- Product number
- 2275EL
- Product name
- N-[(2S,3R,4E)-1,3-Dihydroxyoctadec-4-en-2-yl]-30-hydroxytriacontanamide
- Packaging
- 5mg
- Price
- $1072
- Updated
- 2021/12/16
C30(-hydroxy) Ceramide (d18:1/30:0) Chemical Properties,Usage,Production
Description
C30(ω-hydroxy) Ceramide is a bioactive sphingolipid found in the stratum corneum layer of mammalian epidermis. C30(ω-hydroxy) Ceramide is vital to skin barrier functions and has a role in maturation of epidermis cells of the spermatozoa/testes. C30(ω-hydroxy) Ceramide deficiency causes defective skin-water permeability barrier function and neonatal lethality in elongation of very long chain fatty acids-4 (ELOVL4) deficient mice. [Matreya, LLC. Catalog No. 2080]
Uses
C30(ω-hydroxy) Ceramide (d18:1/30:0), a sphingolipid, is an epidermis-specifically vital component of the water barrier in mammalian skin. C30(ω-hydroxy) Ceramide (d18:1/30:0) is expressed in epidermal keratinocytes and male germ cells during their differentiation and maturation. C30(ω-hydroxy) Ceramide (d18:1/30:0) deficiency in the epiderm of Elovl4 deletion or mutation mice[1][2].
Definition
ChEBI: N-(omega-hydroxytriacontanoyl)sphingosine is an N-acylsphingosine that has omega-hydroxytriacontanoyl as the acyl group. A bioactive sphingolipid found in the stratum corneum layer of mammalian epidermis. It is a N-acylsphingosine, an omega-hydroxy-ultra-long chain fatty acylceramide and a N-(omega-hydroxy-ultra-long chain fatty acyl)sphingosine. It is functionally related to an omega-hydroxytriacontanoic acid.
References
[1] Jennemann R, et al. Integrity and barrier function of the epidermis critically depend on glucosylceramide synthesis. J Biol Chem. 2007 Feb 2;282(5):3083-94. DOI:10.1074/jbc.M610304200
[2] Sandhoff R. Very long chain sphingolipids: tissue expression, function and synthesis. FEBS Lett. 2010 May 3;584(9):1907-13. DOI:10.1016/j.febslet.2009.12.032
C30(-hydroxy) Ceramide (d18:1/30:0) Preparation Products And Raw materials
Raw materials
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