Neurokinin A (trifluoroacetate salt)

Neurokinin A (trifluoroacetate salt) Property

solubility 

Water: 1 mg/ml

Hazard and Precautionary Statements (GHS)

Neurokinin A (trifluoroacetate salt) Chemical Properties,Usage,Production

Description

Neurokinin A is a peptide agonist of the neurokinin-2 (NK2) receptor.1,2,3 It potentiates electrically-induced contractions of isolated rat vas deferens and increases vasodilation in the rat hind paw.2 Neurokinin A (0.3-30 nmol/kg, i.v.) induces bronchoconstriction in guinea pigs in a dose-dependent manner (EC50 = 29 nM), an effect which can be reversed by the NK2 receptor antagonist MEN 10,207.1,3WARNING This product is not for human or veterinary use.

References

[1] C A MAGGI. In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376.[J]. Journal of Pharmacology and Experimental Therapeutics, 1991, 257 3: 1172-1178.
[2] U HOLZER-PETSCHE. In vivo and in vitro actions of mammalian tachykinins.[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 1985, 330 2: 130-135. DOI: 10.1007/bf00499905
[3] ODETTE LANEUVILLE  Cecil R P A  Réjean Couture. Neurokinin A-induced contraction of guinea-pig isolated trachea: potentiation by hepoxilins[J]. British Journal of Pharmacology, 1992, 107 3: 808-812. DOI: 10.1111/j.1476-5381.1992.tb14528.x