AA-CW236

Product Name: AA-CW236
CAS No.: 1869921-96-9
Chemical Name: AA-CW236
Synonyms: AA-CW236;AA-CW236 (AA-CW-236;AA-CW236 >=98% (HPLC);1H-1,2,3-Triazole, 5-(chloromethyl)-1-[2-(3,5-dimethyl-4-isoxazolyl)ethyl]-4-[4-(trifluoromethoxy)phenyl]-
CBNumber: CB84667476
Molecular Formula: C17H16ClF3N4O2
Formula Weight: 400.78
MOL File: 1869921-96-9.mol

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AA-CW236 Property

Boiling point:: 535.0±60.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 25mg/mL protein, clear
form: powder
pka: -0.37±0.10(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1761
Product name: AA-CW236
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $464
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1761
Product name: AA-CW236
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $107
Updated: 2023/06/20

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AA-CW236 Chemical Properties,Usage,Production

Uses

AA-CW236 has been used as an inhibitor of m6G DNA methyltransferase in mouse embryo fibroblasts.

Biochem/physiol Actions

AA-CW236 is a cell-permeable chloromethyl triazole (CMT) derivative that acts as a non-pseudosubstrate inhibitor against human O(6)-alkylguanine DNA methyltransferase (MGMT) by targeting MGMT active site Cys145 for covalent modification (KI = 24 nM, kinact = 0.03/min), displaying little affinity toward cysteines from other cellular proteins. AA-CW236 pretreatment (1 μM) effectively prevents MGMT from repairing DNA damage, causing significantly more upregulated O6-alkylguanine accumulation than the pseudosubstrate inhibitor Lomeguatrib (1 μM) when co-administered with the DNA-alkylating agent Temozolomide/TMZ (300 μM) in MCF-7 cells. Likewise, AA-CW236 is shown to boost TMZ toxicity in Caco-2 cultures (IC50 = 227 and 673 μM, respectively, with or without 3 μM AA-CW236 co-treatment).

AA-CW236 Preparation Products And Raw materials

Raw materials

Preparation Products

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AA-CW236 Suppliers

China 5 United States 2 Global 7

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1869921-96-9, AA-CW236Related Search:

AA-CW236

AA-CW236 (AA-CW-236

1H-1,2,3-Triazole, 5-(chloromethyl)-1-[2-(3,5-dimethyl-4-isoxazolyl)ethyl]-4-[4-(trifluoromethoxy)phenyl]-

AA-CW236 >=98% (HPLC)

1869921-96-9