ChemicalBook > CAS DataBase List > Danicopan

Danicopan

Product Name: Danicopan
CAS No.: 1903768-17-1
Chemical Name: Danicopan
Synonyms: ACH-4471;Danicopan;ACH-0144471;Danicopan（ACH-4471）;Danicopan (ACH-4471) ，S0803;ACH4471,Complement System,ACH 4471,Danicopan,inhibit,Inhibitor;(2S,4R)-1-(2-(3-Acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol-1-yl)acetyl)-N-(6-bromopyridin-2-yl)-4-fluoropyrrolidine-2-carboxamide;2-Pyrrolidinecarboxamide, 1-[2-[3-acetyl-5-(2-methyl-5-pyrimidinyl)-1H-indazol-1-yl]acetyl]-N-(6-bromo-2-pyridinyl)-4-fluoro-, (2S,4R)-
CBNumber: CB84667810
Molecular Formula: C26H23BrFN7O3
Formula Weight: 580.41
MOL File: 1903768-17-1.mol

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Danicopan Property

Boiling point:: 841.7±65.0 °C(Predicted)
Density: 1.61±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:175.0(Max Conc. mg/mL);301.51(Max Conc. mM)
form: A solid
pka: 11.48±0.40(Predicted)
color: White to off-white
InChIKey: PIBARDGJJAGJAJ-NQIIRXRSSA-N
SMILES: N1(C(CN2C3=C(C=C(C4=CN=C(C)N=C4)C=C3)C(C(C)=O)=N2)=O)C[C@H](F)C[C@H]1C(NC1=NC(Br)=CC=C1)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0068562
Product name: Danicopan
Purity: 99.91%
Packaging: 5mg
Price: $330
Updated: 2021/12/16

ChemScene

Product number: CS-0068562
Product name: Danicopan
Purity: 99.91%
Packaging: 25mg
Price: $860
Updated: 2021/12/16

DC Chemicals

Product number: DC11082
Product name: Danicopan(ACH-4471)
Purity: >98%
Packaging: 100mg
Price: $950
Updated: 2021/12/16

DC Chemicals

Product number: DC11082
Product name: Danicopan(ACH-4471)
Purity: >98%
Packaging: 250mg
Price: $1500
Updated: 2021/12/16

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Danicopan Chemical Properties,Usage,Production

Uses

Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS)[1].

References

[1] Yuan X, et al. Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. Haematologica. 2017 Mar;102(3):466-475. DOI:10.3324/haematol.2016.153312
[2] Boyer DD, Ko YP, Podos SD, et al. Danicopan, an Oral Complement Factor D Inhibitor, Exhibits High and Sustained Exposure in Ocular Tissues in Preclinical Studies. Transl Vis Sci Technol. 2022;11(10):37. DOI:10.1167/tvst.11.10.37

Danicopan Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Danicopan manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: Danicopan 1903768-17-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-11-12

1903768-17-1, DanicopanRelated Search:

ACH-0144471

Danicopan

ACH-4471

Danicopan（ACH-4471）

2-Pyrrolidinecarboxamide, 1-[2-[3-acetyl-5-(2-methyl-5-pyrimidinyl)-1H-indazol-1-yl]acetyl]-N-(6-bromo-2-pyridinyl)-4-fluoro-, (2S,4R)-

(2S,4R)-1-(2-(3-Acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol-1-yl)acetyl)-N-(6-bromopyridin-2-yl)-4-fluoropyrrolidine-2-carboxamide

ACH4471,Complement System,ACH 4471,Danicopan,inhibit,Inhibitor

Danicopan (ACH-4471) ，S0803

1903768-17-1

C26H23BrFN7O3