Dynarrestin

Product Name: Dynarrestin
CAS No.: 2222768-84-3
Chemical Name: Dynarrestin
Synonyms: Dynarrestin;Dynarrestin >=98% (HPLC);Dynarrestin, 10 mM in DMSO;Dynarrestin,Hedgehog,Inhibitor,inhibit;Ethyl 4-(4-(diethylamino)phenyl)-2-((2,4-difluorophenyl)amino)thiazole-5-carboxylate;ethyl 4-[4-(diethylamino)phenyl]-2-[(2,4-difluorophenyl)amino]-1,3-thiazole-5-carboxylate;5-Thiazolecarboxylic acid, 4-[4-(diethylamino)phenyl]-2-[(2,4-difluorophenyl)amino]-, ethyl ester
CBNumber: CB84667850
Molecular Formula: C22H23F2N3O2S
Formula Weight: 431.5
MOL File: 2222768-84-3.mol

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Dynarrestin Property

storage temp.: 4°C, protect from light ,unstable in solution, ready to use.
solubility: Soluble in DMSO
form: A solid
color: Light brown to brown
InChI: 1S/C22H23F2N3O2S/c1-4-27(5-2)16-10-7-14(8-11-16)19-20(21(28)29-6-3)30-22(26-19)25-18-12-9-15(23)13-17(18)24/h7-13H,4-6H2,1-3H3,(H,25,26)
InChIKey: UZNNDDDSGCMQOQ-UHFFFAOYSA-N
SMILES: CCN(CC)C1=CC=C(C2=C(C(OCC)=O)SC(NC3=C(F)C=C(F)C=C3)=N2)C=C1

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 6526
Product name: Dynarrestin
Purity: ≥98%(HPLC)
Packaging: 5
Price: $259
Updated: 2021/12/16

TRC

Product number: D826550
Product name: Dynarrestin
Packaging: 5mg
Price: $235
Updated: 2021/12/16

ChemScene

Product number: CS-0083323
Product name: Dynarrestin
Packaging: 5mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-0083323
Product name: Dynarrestin
Packaging: 10mg
Price: $170
Updated: 2021/12/16

ChemScene

Product number: CS-0083323
Product name: Dynarrestin
Packaging: 50mg
Price: $450
Updated: 2021/12/16

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Dynarrestin Chemical Properties,Usage,Production

Uses

Dynarrestin is an dynein inhibitor. Inhibits hedgehog signaling in vitro (IC50 = 0.22 μM). Exhibits reversible inhibition of cytoplasmic dynein 1-dependent microtubule binding and cytoplasmic dynein 2-dependent intraflagellar transport. Inhibits tumor cell proliferation in a mouse medulloblastoma model.

Biological Activity

Dynarrestin is a potent and selective reversible inhibitor of cytoplasmic dyneins 1 and 2 th at inhibits dynein 1-dependent microtubule binding and motility without affecting ATP hydrolysis. It inhibits endosome movement and disturbs mitosis in cells. Dynarrestin inhibits dynein 2-mediated intraflagellar transport of the cargo IFT88 and flux of Smo within cilia. Also it inhibits cancer cells proliferation downstream of Smo.', 'Dynarrestin is an aminothiazole derivative, which can bind to protein tyrosine phosphatase interacting protein 51 (PTPIP51). This interaction helps in regulating various signaling pathways th at lead to proliferation and migration. Dynarrestin blocks hedgehog (Hh)-dependent signaling in mouse and human cells.

storage

Store at -20°C

Dynarrestin Preparation Products And Raw materials

Raw materials

Preparation Products

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Dynarrestin Suppliers

CHINA 45 United Kingdom 1 United States 4 Global 50

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2222768-84-3, DynarrestinRelated Search:

Dynarrestin

Ethyl 4-(4-(diethylamino)phenyl)-2-((2,4-difluorophenyl)amino)thiazole-5-carboxylate

5-Thiazolecarboxylic acid, 4-[4-(diethylamino)phenyl]-2-[(2,4-difluorophenyl)amino]-, ethyl ester

Dynarrestin >=98% (HPLC)

Dynarrestin,Hedgehog,Inhibitor,inhibit

ethyl 4-[4-(diethylamino)phenyl]-2-[(2,4-difluorophenyl)amino]-1,3-thiazole-5-carboxylate

Dynarrestin, 10 mM in DMSO

2222768-84-3

C22H23F2N3O2S