GAT-211

Product Name: GAT-211
CAS No.: 102704-40-5
Chemical Name: GAT-211
Synonyms: AZ4;AZ 4;AZ-4;GAT-211;GAT211 >=98% (HPLC);3-(2-nitro-1-phenylethyl)-2-phenyl-1H-indole;1H-Indole, 3-(2-nitro-1-phenylethyl)-2-phenyl-
CBNumber: CB84667931
Molecular Formula: C22H18N2O2
Formula Weight: 342.39
MOL File: 102704-40-5.mol

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GAT-211 Property

storage temp.: Store at -20°C
solubility: DMF: 25 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
form: A crystalline solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1926
Product name: GAT211
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $467
Updated: 2026/03/19

Sigma-Aldrich

Product number: SML1926
Product name: GAT211
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $86.1
Updated: 2025/07/31

Cayman Chemical

Product number: 24484
Product name: GAT211
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 24484
Product name: GAT211
Packaging: 5mg
Price: $172
Updated: 2024/03/01

AK Scientific

Product number: 7131CM
Product name: 3-(2-Nitro-1-phenylethyl)-2-phenyl-1H-indole
Packaging: 5mg
Price: $289
Updated: 2021/12/16

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GAT-211 Chemical Properties,Usage,Production

Description

GAT211, aslo known as AZ-4, is a small molecule CB1 positive allosteric modulator. GAT211 suppresses allodynia and produces synergistic antiallodynic effects with fatty acid amide hydrolase and monoacylglycerol lipase inhibitors in paclitaxel-treated mice. Positive allosteric modulation of CB1-receptor signaling with GAT211shows promise as a safe and effective analgesic strategy that lacks tolerance, dependence, and abuse liability.

Uses

GAT211 is a cannabinoid 1 receptor (CB1R) positive allosteric modulator (PAM). GAT211 activates cAMP and β-arrestin2 with EC50 values of 260 nM and 650 nM, respectively. GAT211 inhibits GAT211 can be used for neuropathic and/or inflammatory pain research[1].

in vivo

GAT211 potentiates the inhibition of electrically evoked vas deferens contraction in the same system (EC₅₀=11 nM, E_max=70)^[2].
GAT211 (0.3 mg/kg, 1 mg/kg, 3 mg/kg; 5 mL/kg; ip; 2 doses with 5 min interval) dose-dependently reduced locomotor activity and the acoustic startle response.GAT211 is dissolved in a vehicle of ethanol, kolliphor, and saline at a ratio of 1:1:6 and injected at a volume of 5 mL/kg^[3].

IC 50

CB1

References

[1] Garai S, et al. Design, synthesis, and pharmacological profiling of cannabinoid 1 receptor allosteric modulators: Preclinical efficacy of C2-group GAT211 congeners for reducing intraocular pressure. Bioorg Med Chem. 2021 Nov 15;50:116421. DOI:10.1016/j.bmc.2021.116421
[2] McElroy DL, et al. Antipsychotic potential of the type 1 cannabinoid receptor positive allosteric modulator GAT211: preclinical in vitro and in vivo studies. Psychopharmacology (Berl). DOI:10.1007/s00213-020-05755-x
[3] Richard A Slivicki, et al. Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence. Biol Psychiatry. 2018 Nov 15;84(10):722-733. DOI:10.1016/j.biopsych.2017.06.032

GAT-211 Preparation Products And Raw materials

Raw materials

Preparation Products

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GAT-211 Suppliers

China 17 United States 4 Global 21

BOC Sciences

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Shanghai YuanYe Biotechnology Co., Ltd.

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Shanghai Hongye Biotechnology Co. Ltd

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TargetMol Chemicals Inc.

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HANGZHOU CLAP TECHNOLOGY CO.,LTD

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Energy Chemical

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TargetMol Chemicals Inc.

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Shanghai Yifei Biotechnology Co. , Ltd.

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102704-40-5, GAT-211Related Search:

GAT-211

3-(2-nitro-1-phenylethyl)-2-phenyl-1H-indole

1H-Indole, 3-(2-nitro-1-phenylethyl)-2-phenyl-

GAT211 >=98% (HPLC)

AZ 4

AZ4

AZ-4

102704-40-5