MYCMI-6

Product Name: MYCMI-6
CAS No.: 681282-09-7
Chemical Name: MYCMI-6
Synonyms: MYCMI-6;NSC354961;MYCMI-6(NSC 354961);MYCMI-6/681282-09-7;3-((9-Amino-7-ethoxyacridin-3-yl)diazenyl)pyridine-2,6-diamine;2,6-Pyridinediamine, 3-[2-(9-amino-7-ethoxy-3-acridinyl)diazenyl]-;NSC 354961,cells,neuroblastoma,cytotoxic,mice,tumor,inhibit,nude,lymphoma,MYCMI-6,athymic,Inhibitor,NSC-354961,MYC-driven,Apoptosis,Myc,c-Myc,MYCMI6,MCF7,MYCMI 6
CBNumber: CB84668251
Molecular Formula: C20H19N7O
Formula Weight: 373.41
MOL File: 681282-09-7.mol

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MYCMI-6 Property

Boiling point:: 699.5±55.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 7.53±0.10(Predicted)
form: Solid
color: Brown to reddish brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ambeed

Product number: A1329217
Product name: 3-((9-Amino-7-ethoxyacridin-3-yl)diazenyl)pyridine-2,6-diamine
Purity: 98%
Packaging: 1mg
Price: $250
Updated: 2021/12/16

Ambeed

Product number: A1329217
Product name: 3-((9-Amino-7-ethoxyacridin-3-yl)diazenyl)pyridine-2,6-diamine
Purity: 98%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

Ambeed

Product number: A1329217
Product name: 3-((9-Amino-7-ethoxyacridin-3-yl)diazenyl)pyridine-2,6-diamine
Purity: 98%
Packaging: 10mg
Price: $720
Updated: 2021/12/16

DC Chemicals

Product number: DC10952
Product name: MYCMI-6(NSC354961)
Purity: >98%
Packaging: 250mg
Price: $950
Updated: 2021/12/16

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MYCMI-6 Chemical Properties,Usage,Production

Uses

MYCMI-6 (NSC354961) is a potent and selective endogenous MYC:MAX protein interactions inhibitor. MYCMI-6 blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with a Kd of 1.6μM. MYCMI-6 inhibits tumor cell growth in a MYC-dependent manner (IC50<0.5μM). MYCMI-6 is not cytotoxic to normal human cells. MYCMI-6 induces apoptosis[1].

in vivo

MYCMI-6 (20 mg/kg; i.p.; daily for 1-2 weeks) induces massive apoptosis and reduces tumor cell proliferation, tumor microvasculature density and MYC:MAX interaction in a MYC-dependent xenograft tumor model^[1].

Animal Model:	6-8 weeks old athymic nude mice (bearing MYCN-amplified SK-N-DZ neuroblastoma cells)^[1]
Dosage:	20mg/kg body weight
Administration:	I.p.; daily for 1-2 weeks
Result:	A dramatic increase in the extension of apoptotic areas in the tumors and a significant increase in non-proliferative areas as determined by Ki67 staining in tumors.

References

[1] Castell A, et al. A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation. Sci Rep. 2018 Jul 3;8(1):10064. DOI:10.1038/s41598-018-28107-4

MYCMI-6 Preparation Products And Raw materials

Raw materials

Preparation Products

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MYCMI-6 Suppliers

China 32 United States 4 Global 36

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 89689
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9550
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
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Henan Weituxi Chemical Technology Co., Ltd.

Tel: 0371-63284658 18135795563
Fax: QQ:2885349392
Email: 3905209149@qq.com
Country: China
ProdList: 9870
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BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19552
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Jingmo (Xiamen) Biotechnology Co., Ltd

Tel: 13621943973; 13621943973
Email: sales@jamxmpharmatech.com
Country: China
ProdList: 1180
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

681282-09-7, MYCMI-6Related Search:

MYCMI-6

NSC354961

2,6-Pyridinediamine, 3-[2-(9-amino-7-ethoxy-3-acridinyl)diazenyl]-

MYCMI-6(NSC 354961)

3-((9-Amino-7-ethoxyacridin-3-yl)diazenyl)pyridine-2,6-diamine

NSC 354961,cells,neuroblastoma,cytotoxic,mice,tumor,inhibit,nude,lymphoma,MYCMI-6,athymic,Inhibitor,NSC-354961,MYC-driven,Apoptosis,Myc,c-Myc,MYCMI6,MCF7,MYCMI 6

MYCMI-6/681282-09-7

681282-09-7