PHY34
- Product Name
- PHY34
- CAS No.
- 2130033-55-3
- Chemical Name
- PHY34
- Synonyms
- PHY34;PHY34 ，S8744;PHY-34,PHY34;Naphtho[2,3-c]furan-1(3H)-one, 9-(1,3-benzodioxol-5-yl)-6,7-dimethoxy-4-[[3,4-O-(1-methylethylidene)-β-D-galactopyranosyl]oxy]-
- CBNumber
- CB84668387
- Molecular Formula
- C30H30O12
- Formula Weight
- 582.56
- MOL File
- 2130033-55-3.mol
PHY34 Property
- Boiling point:
- 841.4±65.0 °C(Predicted)
- Density
- 1.412±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 10 mg/ml
- form
- A solid
- pka
- 12.43±0.70(Predicted)
- color
- White to off-white
- InChIKey
- PMJUVXNBXQVOOP-VITQGGQRNA-N
- SMILES
- O=C1OCC2=C(O[C@@H]3O[C@H](CO)[C@]4([H])OC(C)(C)O[C@]4([H])[C@H]3O)C3=CC(OC)=C(OC)C=C3C(C3=CC=C4OCOC4=C3)=C12 |&1:7,9,12,19,21,r|
PHY34 Chemical Properties,Usage,Production
Uses
PHY34 is an inhibitor that inhibits ATP6V0A2 and CAS thereby inhibiting autophagy, and has a nanomolar effect. PHY34 inhibits cancer cell growth by inducing apoptosis and inhibits tumor growth in xenograft models. PHY34 can be used for research on high grade serous ovarian cancer[1][2].
in vivo
PHY34 (0.75 mg/kg, i.p., 3 times a week for 3 weeks) inhibits tumor growth and reduces Ki67 expression in tumor tissue in a female nude mouse tumor bearing model constructed by OVCAR8[1].
PHY34 Pharmacokinetics[1]
| Parameter | Units | IV | IP | PO |
| Dose | mg/kg | 0.6 | 1.8 | 75 |
| Dose | nmol | 1029.9 | 3089.8 | 128742.1 |
| T1/2 | hr | 6.2 | 8.4 | 12.3 |
| Tmax | hr | 0.08 | 0.25 | 0.25 |
| Cmax | nmol/L | 288.8 | 519.5 | 323.6 |
| AUClast | hr*nmol/L | 198.8 | 360.5 | 599.9 |
| AUCinf | hr*nmol/L | 215.8 | 366.5 | 663.3 |
| Vz | L/kg | 42.7 | 101.6 | 3430.3 |
| CI | L/hr/kg | 4.8 | 8.4 | 194.1 |
| MRT | hr | 6.1 | 1.9 | 7.8 |
| F* | % | - | 56.6 | 2.5 |
| Animal Model: | OVCAR8-induced xenograft models in female nude mice[1]. |
| Dosage: | 0.75 mg/kg, three times a week for three weeks |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Decreased tumor burden based on average abdominal radiant efficiency with no gross toxicity through analysis of fluorescence imaging. |
References
[1] Young AN,et al. Phyllanthusmin Derivatives Induce Apoptosis and Reduce Tumor Burden in High-Grade Serous Ovarian Cancer by Late-Stage Autophagy Inhibition. Mol Cancer Ther. 2018 Oct;17(10):2123-2135. DOI:10.1158/1535-7163.MCT-17-1195
[2] Salvi A, et al. PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer. Cell Death Dis. 2022 Jan 10;13(1):45. DOI:10.1038/s41419-021-04495-w
PHY34 Preparation Products And Raw materials
Raw materials
Preparation Products
PHY34 Suppliers
- Tel
- 010-010-62452898 13581984929
- Fax
- 010-62452898
- jlzhang929@163.com
- Country
- China
- ProdList
- 89
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9803
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 86249
- Advantage
- 60
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 7999
- Advantage
- 62
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32467
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44896
- Advantage
- 58
- Tel
- +86-02787215551 19945035818
- Fax
- 027-87215551
- 2936752263@qq.com
- Country
- China
- ProdList
- 7975
- Advantage
- 58
- Tel
- 15071299552
- Fax
- QQ:262933239
- 262933239@qq.com
- Country
- China
- ProdList
- 7104
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24960
- Advantage
- 58