Raphin1

Product Name: Raphin1
CAS No.: 2022961-17-5
Chemical Name: Raphin1
Synonyms: Raphin1;PPP1-R15B inhibitor;phosphatase inhibitor;Raphin1, 10 mM in DMSO;Raphin1 (PPP1R15B inhibitor Raphin1);Raphin1,Raphin 1,Raphin-1,Phosphatase,inhibit,Inhibitor;(E)-2-(2,3-Dichlorobenzylidene)hydrazine-1-carboximidamide;(2E)-2-[(2,3-Dichlorophenyl)methylene]hydrazinecarboximidamide;Hydrazinecarboximidamide, 2-[(2,3-dichlorophenyl)methylene]-, (2E)-;RAPHIN1;RAPHIN 1;RAPHIN-1;PHOSPHATASE INHIBITOR; PPP1-R15B INHIBITOR
CBNumber: CB84668433
Molecular Formula: C8H8Cl2N4
Formula Weight: 231.08
MOL File: 2022961-17-5.mol

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Raphin1 Property

Boiling point:: 360.1±52.0 °C(Predicted)
Density: 1.49±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 125 mg/mL (540.94 mM)
pka: 8.37±0.50(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 6760
Product name: Raphin1
Purity: ≥98%(HPLC)
Packaging: 10
Price: $155
Updated: 2021/12/16

Tocris

Product number: 6760
Product name: Raphin1
Purity: ≥98%(HPLC)
Packaging: 50
Price: $647
Updated: 2021/12/16

Axon Medchem

Product number: Axon3004
Product name: Raphin1
Purity: 98%
Packaging: 10mg
Price: $115.5
Updated: 2021/12/16

Axon Medchem

Product number: Axon3004
Product name: Raphin1
Purity: 98%
Packaging: 50mg
Price: $401.5
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0009807
Product name: PHOSPHATASE INHIBITOR
Purity: 95.00%
Packaging: 5MG
Price: $455.41
Updated: 2021/12/16

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Raphin1 Chemical Properties,Usage,Production

Uses

Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease[1].

in vivo

Raphin1 improves weight of HD^82Q mice treated from 4 to ～10 weeks of age with 2 mg/kg of Raphin1 once a day by oral gavage. Raphin1 also decreases SDS-insoluble huntingtin assemblies and nuclear inclusions in the cortex of HD^82Q mice^[1].

storage

Store at -20°C

References

[1] Krzyzosiak A, et al. Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018 Aug 23;174(5):1216-1228.e19. DOI:10.1016/j.cell.2018.06.030

Raphin1 Preparation Products And Raw materials

Raw materials

Preparation Products

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Raphin1 Suppliers

China 36 United Kingdom 1 United States 4 Global 41

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39999
Advantage: 60

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7777
Advantage: 56

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 88915
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 9697
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 7999
Advantage: 62

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
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Advantage: 58

Shandong Jirun Biomedical Technology Co., Ltd.

Tel: 0539-0539-8613587 17661611089
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Email: 2639273505@qq.com
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Shanghai Zeye Biotechnology Co., Ltd.

Tel: 021-57896695 13122364865
Email: sale1@shzysw.net
Country: China
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2022961-17-5, Raphin1Related Search:

(2E)-2-[(2,3-Dichlorophenyl)methylene]hydrazinecarboximidamide

Raphin1

phosphatase inhibitor

PPP1-R15B inhibitor

RAPHIN1;RAPHIN 1;RAPHIN-1;PHOSPHATASE INHIBITOR; PPP1-R15B INHIBITOR

Hydrazinecarboximidamide, 2-[(2,3-dichlorophenyl)methylene]-, (2E)-

(E)-2-(2,3-Dichlorobenzylidene)hydrazine-1-carboximidamide

Raphin1,Raphin 1,Raphin-1,Phosphatase,inhibit,Inhibitor

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Raphin1 (PPP1R15B inhibitor Raphin1)

2022961-17-5