1,3-Cyclobutanedicarboxylic acid, 2,4-diphenyl-, 1-(1-naphthalenyl) ester, (1β,2R,3α,4R)-
- Product Name
- 1,3-Cyclobutanedicarboxylic acid, 2,4-diphenyl-, 1-(1-naphthalenyl) ester, (1β,2R,3α,4R)-
- CAS No.
- 1541209-75-9
- Chemical Name
- 1,3-Cyclobutanedicarboxylic acid, 2,4-diphenyl-, 1-(1-naphthalenyl) ester, (1β,2R,3α,4R)-
- Synonyms
- Sb-fi-26;1,3-Cyclobutanedicarboxylic acid, 2,4-diphenyl-, 1-(1-naphthalenyl) ester, (1β,2R,3α,4R)-;SBFI-26 2,4-Diphenyl-cyclobutane-1,3-dicarboxylic acid mono- naphthalen-1-yl ester monosodium salt
- CBNumber
- CB84668488
- Molecular Formula
- C28H22O4
- Formula Weight
- 422.48
- MOL File
- 1541209-75-9.mol
1,3-Cyclobutanedicarboxylic acid, 2,4-diphenyl-, 1-(1-naphthalenyl) ester, (1β,2R,3α,4R)- Property
- Boiling point:
- 641.1±55.0 °C(Predicted)
- Density
- 1.284±0.06 g/cm3(Predicted)
- solubility
- Acetonitrile: Slightly Soluble: 0.1-1 mg/mL
DMSO: Sparingly Soluble: 1-10mg/mL - pka
- 4.07±0.70(Predicted)
- InChIKey
- NVOKBONTLOAJKA-BNZGOVKJNA-N
- SMILES
- C([C@H]1[C@H](C2C=CC=CC=2)[C@H](C(=O)O)[C@H]1C1C=CC=CC=1)(=O)OC1=CC=CC2C=CC=CC1=2 |&1:1,2,9,13,r|
1,3-Cyclobutanedicarboxylic acid, 2,4-diphenyl-, 1-(1-naphthalenyl) ester, (1β,2R,3α,4R)- Chemical Properties,Usage,Production
Description
SB-FI-26 is an inhibitor of fatty acid binding protein 5 (FABP5) and FABP7 (Kis = 0.93 and 0.4 µM, respectively).1,2 It inhibits arachidonoyl ethanolamide (AEA; Item No. 90050) uptake in wild-type but not FABP5-/- HeLa cells when used at a concentration of 20 µM.1 In vivo, SB-FI-26 (20 mg/kg) reduces nocifensive behavior in phase one of the formalin test and carrageenan-induced thermal hyperalgesia in mice.WARNING This product is not for human or veterinary use.
References
[1] WILLIAM T BERGER. Targeting fatty acid binding protein (FABP) anandamide transporters - a novel strategy for development of anti-inflammatory and anti-nociceptive drugs.[J]. PLoS ONE, 2012: e50968. DOI: 10.1371/journal.pone.0050968
[2] HAO-CHI HSU. The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites[J]. Biochemistry Biochemistry, 2017, 56 27: 3454-3462. DOI: 10.1021/acs.biochem.7b00194
1,3-Cyclobutanedicarboxylic acid, 2,4-diphenyl-, 1-(1-naphthalenyl) ester, (1β,2R,3α,4R)- Preparation Products And Raw materials
Raw materials
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