TR antagonist 1

Product Name: TR antagonist 1
CAS No.: 500794-88-7
Chemical Name: TR antagonist 1
Synonyms: TR antagonist 1;Benzenepropanoic acid, 3,5-dibromo-4-[4-hydroxy-3-(1-methylethyl)-5-[(1E)-2-(4-pyridinyl)ethenyl]phenoxy]-
CBNumber: CB84672641
Molecular Formula: C25H23Br2NO4
Formula Weight: 561.26
MOL File: 500794-88-7.mol

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TR antagonist 1 Property

Boiling point:: 636.5±55.0 °C(Predicted)
Density: 1.553±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO : ≥ 83.3 mg/mL (148.42 mM)
pka: 4.51±0.10(Predicted)
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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TR antagonist 1 Chemical Properties,Usage,Production

Uses

TR antagonist 1 is a high-affinity thyroid hormone receptor (TR) antagonist with IC50s of 36 and 22 nM for TRα and TRβ, respectively.

in vivo

TR antagonist 1 treatment lowers heart rate and shows a possible trend toward an increase of low-density lipoprotein cholesterol (LDL-C) in the cholesterol fed rat model^[1].

References

[1] Koehler K, et al. Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor. J Med Chem. 2006 Nov 16;49(23):6635-7. DOI:10.1021/jm060521i

TR antagonist 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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TR antagonist 1 Suppliers

China 20 United States 3 Global 23

Nanjing Norris-Pharm Technology Co., Ltd

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500794-88-7, TR antagonist 1Related Search:

TR antagonist 1

Benzenepropanoic acid, 3,5-dibromo-4-[4-hydroxy-3-(1-methylethyl)-5-[(1E)-2-(4-pyridinyl)ethenyl]phenoxy]-

500794-88-7