LJ570

Product Name: LJ570
CAS No.: 2252488-69-8
Chemical Name: LJ570
Synonyms: LJ570;LJ570, 10 mM in DMSO;1,1'-Biphenyl]-4-propanoic acid,α-([1,1'-biphenyl]-4-yloxy)-,(αS)-;[1,1'-Biphenyl]-4-propanoic acid, α-([1,1'-biphenyl]-4-yloxy)-, (αS)-;(2S)-2-{[1,1'-biphenyl]-4-yloxy}-3-{[1,1'-biphenyl]-4-yl}propanoic acid;inhibit,Peroxisome proliferator-activated receptors,LJ-570,LJ 570,LJ570,Inhibitor,PPAR
CBNumber: CB84676593
Molecular Formula: C27H22O3
Formula Weight: 394.47
MOL File: 2252488-69-8.mol

More

Less

LJ570 Property

Boiling point:: 601.0±55.0 °C(Predicted)
Density: 1.185±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 2.96±0.10(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

DC Chemicals

Product number: DC33576
Product name: LJ570
Packaging: 100mg
Price: $800
Updated: 2021/12/16

More

Less

LJ570 Chemical Properties,Usage,Production

Description

LJ570 is the first PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation. LJ570 is a potent partial agonist of both PPARα and γ subtypes. LJ570 inhibited the Cdk5-mediated phosphorylation of PPARγ at serine 273 that is currently considered the mechanism by which some PPARγ partial agonists exert antidiabetic effects similar to thiazolidinediones, without showing their typical side effects. LJ570 may be useful for treatment of dyslipidemic type 2 diabetes.

Uses

LJ570 is a PPARα/PPARγ dual agonist with EC50s of 1.05 and 0.12 μM, respectively[1].

target

LJ570 is the first PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation.

IC 50

PPARα: 1.05 μM (EC₅₀); PPARγ: 0.12 μM (EC₅₀)

References

[1] Laghezza A, et al. Identification of the First PPARα/γ Dual Agonist Able To Bind to Canonical and Alternative Sites of PPARγ and To Inhibit Its Cdk5-Mediated Phosphorylation. J Med Chem. 2018 Sep 27;61(18):8282-8298. DOI:10.1021/acs.jmedchem.8b00835

LJ570 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

LJ570 Suppliers

China 30 United States 3 Global 33

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4800
Advantage: 55

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9531
Advantage: 58

Chuzhou KeMail Chemical Technology Co., Ltd

Tel: 0550-5196001 15000891977
Fax: 0550-5196001
Email: wj520wjxby@126.com
Country: China
ProdList: 1945
Advantage: 55

JinJin Le Chemical Co., Ltd

Tel: 18001959627(微信同号) 18001959627
Email: jjlchem2@163.com
Country: China
ProdList: 9981
Advantage: 58

Fujian boshi pharmaceutical technology co. LTD

Tel: 0595-22008920; 18120708884
Email: 393612455@qq.com
Country: China
ProdList: 255
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32470
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471 +1-2135480471;
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15727060112
Email: yutianchun2007@126.com
Country: China
ProdList: 9815
Advantage: 58

2252488-69-8, LJ570Related Search:

LJ570

[1,1'-Biphenyl]-4-propanoic acid, α-([1,1'-biphenyl]-4-yloxy)-, (αS)-

1,1'-Biphenyl]-4-propanoic acid,α-([1,1'-biphenyl]-4-yloxy)-,(αS)-

inhibit,Peroxisome proliferator-activated receptors,LJ-570,LJ 570,LJ570,Inhibitor,PPAR

(2S)-2-{[1,1'-biphenyl]-4-yloxy}-3-{[1,1'-biphenyl]-4-yl}propanoic acid

LJ570, 10 mM in DMSO

2252488-69-8