ChemicalBook > CAS DataBase List > Apigenin 7-glucoside

Apigenin 7-glucoside

Product Name
Apigenin 7-glucoside
CAS No.
578-74-5
Chemical Name
Apigenin 7-glucoside
Synonyms
COSMOSIIN;APIGETRIN;APIGENIN-7-O-GLUCOSIDE;COSMETIN;APIGENIN-7-GLUCOSIDE;Apigenin-7-O-β-D-glucoside;Apigenin-7-O-β-D-glucopyranoside;Apigenin-7-O-β-D-glucopyranoside;apigenin 7-O-β-D-glucoside;Cosmosioside
CBNumber
CB8468248
Molecular Formula
C21H20O10
Formula Weight
432.38
MOL File
578-74-5.mol
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Apigenin 7-glucoside Property

Melting point:
230-237°C
Boiling point:
788.9±60.0 °C(Predicted)
Density 
1.642±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO (Slightly, Sonicated), Methanol (Slightly)
pka
6.13±0.40(Predicted)
form 
Solid
color 
Pale Yellow to Yellow
BRN 
65669
Stability:
Hygroscopic
InChIKey
KMOUJOKENFFTPU-YUVSVTSJNA-N
SMILES
C1(C2=CC=C(O)C=C2)OC2=C(C(=CC(OC3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)=C2)O)C(=O)C=1 |&1:17,20,22,24,r|
LogP
-0.040 (est)
CAS DataBase Reference
578-74-5(CAS DataBase Reference)
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Safety

Safety Statements 
34/35
WGK Germany 
3
3-10
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
44692
Product name
Apigenin 7-glucoside
Purity
analytical standard
Packaging
5mg
Price
$235
Updated
2024/03/01
Sigma-Aldrich
Product number
44692
Product name
Apigenin 7-glucoside
Purity
analytical standard
Packaging
25mg
Price
$737.6
Updated
2024/03/01
Sigma-Aldrich
Product number
00720585
Product name
Apigenin 7-glucoside
Purity
primary pharmaceutical reference standard
Packaging
10mg
Price
$722
Updated
2024/03/01
Cayman Chemical
Product number
26813
Product name
Apigenin 7-glucoside
Packaging
10mg
Price
$108
Updated
2024/03/01
Cayman Chemical
Product number
26813
Product name
Apigenin 7-glucoside
Packaging
50mg
Price
$422
Updated
2024/03/01
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Apigenin 7-glucoside Chemical Properties,Usage,Production

Uses

Apigenin 7-Glucoside is a by-product during the synthesis of Isorhoifolin (I819700), a naturally occurring flavonoid that was shown to exhibit potential antidiabetic, antihyperlipidemic and antioxidant effects.

Definition

ChEBI: A glycosyloxyflavone that is apigenin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.

Application

Apigenin 7-glucoside is a flavonoid with anti-inflammatory and anxiolytic activities. It inhibits LPS-induced nitric oxide production in RAW 264.7 cells when used at concentrations ranging from 0.16 to 10 μM. In vivo, apigenin 7-glucoside (10 mg/kg) reduces pulmonary edema and lung inflammation in a mouse model of LPS-induced acute lung injury. It also increases the number of entries and the time spent in the open arms of the elevated plus maze in rats, indicating anxiolytic activity.

Biological Functions

Apigenin 7-glucoside inhibited HL-60 cell growth, dose- and time-dependently, but did not cause apoptosis. The distribution of cells at different stages in the cell cycle indicated an accumulation of treated cells in the G2/M phase. Moreover, apigenin 7-glucoside induced granulocytic differentiation of HL-60 cells[1].

References

[1] Eri Nakazaki. “Proteomic study of granulocytic differentiation induced by apigenin 7-glucoside in human promyelocytic leukemia HL-60 cells.” European Journal of Nutrition 52 1 (2013): 25–35.

Apigenin 7-glucoside Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Apigenin 7-glucoside manufacturers

Bonerge(Hunan) Lifescience Co., Ltd.
Product
Apigenin 7-glucoside 578-74-5
Price
US $0.00/kg
Min. Order
25kg
Purity
99%
Supply Ability
8 tons
Release date
2023-06-02
Shaanxi Haibo Biotechnology Co., Ltd
Product
Apigenin 7-glucoside 578-74-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000ton
Release date
2023-09-07
Shanghai Standard Technology Co., Ltd.
Product
Apigenin 7-glucoside 578-74-5
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-11-22

578-74-5, Apigenin 7-glucosideRelated Search:


  • COSMETIN
  • 4H-1-Benzopyran-4-one,7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)
  • Apigenin 7-beta-D-glucoside
  • Apigenin 7-glucoside SynonyMs:Apigetrin
  • Apigenin 7-b-D-glucoside
  • 4H-1-Benzopyran-4-one,7-(b-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-
  • Apigenin 7-glucoside, >=98%
  • Apigetrin(Apigenin-7-O-glucoside)
  • 5-Hydroxy-2-(4-hydroxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
  • Apigenin 7-glucoside, 98%, from Dendranthema indicum (L.) Des Moul.
  • 5-hydroxy-2-(4-hydroxyphenyl)-7-[[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-1-benzopyran-4-one
  • Apigenin 7-glucoside, BR
  • Apigenin, 7-β-D-glucopyranoside
  • COSMIIN
  • COSMOSIIN
  • APIGENIN-7-O-GLUCOSIDE
  • APIGENIN-7-GLUCOSIDE
  • APIGETRIN
  • 7-O-BETA-D-GLUCOPYRANOSYLOXY-4',5-DIHYDROXYFLAVONE
  • 7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
  • 4H-1-Benzopyran-4-one, 7- (.beta.-D-glucopyranosyloxy)-5-hydroxy-2-(4- hydroxyphenyl)-
  • APIGENIN-7-O-GLUCOSIDE WITH HPLC
  • Apigetrin, Cosmosiin
  • Apigenin 7-β-D-glucoside
  • Cosmosioside
  • 4H-1-Benzopyran-4-one, 7-(beta-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)- (9ci)
  • 7-o-(beta-D-Glucosyl)apigenin
  • Apigenin, 7-beta-D-glucopyranoside
  • Cosemetin
  • APIGENIN-7-GLUCOSIDE (COSMOSIIN)(P)
  • APIGENIN-7-O-GLUCOSIDE hplc
  • Apigenin-7-O-β-D-glucopyranoside
  • APIGENIN-7-O-GLUCOSIDE (COSMOSIIN)(P)
  • APIGENIN-7-O-GLUCOSIDE (COSMOSIIN)(SH)
  • Apigenin-7-O-β-D-glucoside
  • Apigenin 7-glucoside (Apigenin-7-O-β-D-glucopyranoside
  • Apigenin 7-glucoside CRS
  • Thalictiin
  • 5-Hydroxy-2-(4-hydroxyphenyl)-7-((2S,3S,4S,5S)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one
  • apigenin 7-O-β-D-glucoside
  • Apigenin 7-O-β-glucoside
  • Apigenin 7-glucoside USP/EP/BP
  • 5-hydroxy-2-(4-hydroxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
  • Apigetrin (Apigenin-7-O-β-D-glucopyranoside
  • 7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-...
  • Apigenin-7-O-β-D-glucopyranoside
  • Cosmoside
  • Apigenin 7-glucoside-RM
  • Apigenin-7-O-Glucoside(P)
  • 578-74-5
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  • Analytical Chromatography Product Catalog
  • chemical reagent
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  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract