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THYROID HORMONE RECEPTOR ANTAGONIST, 1-850

Product Name
THYROID HORMONE RECEPTOR ANTAGONIST, 1-850
CAS No.
251310-57-3
Chemical Name
THYROID HORMONE RECEPTOR ANTAGONIST, 1-850
Synonyms
TR ANTAGONIST 1-850;THYROID HORMONE RECEPTOR ANTAGONIST, 1-850;1-[[2-[1-(4-nitrophenyl)piperidin-4-ylidene]acetyl]amino]-3-[3-(trifluoromethyl)phenyl]urea;2-(2-(-(4-NITROPHENYL)-4-PIPERIDINYLIDENE)ACETYL)-N-(3-(TRIFLUOROMETHYL) PHENYL)-1-HYDRAZINE CARBOXAMIDE;Acetic acid, 2-[1-(4-nitrophenyl)-4-piperidinylidene]-, 2-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]hydrazide
CBNumber
CB8468369
Molecular Formula
C21H20F3N5O4
Formula Weight
463.41
MOL File
Mol file
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THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 Property

Density 
1.464±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≤0.5mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide
form 
crystalline solid
pka
9.75±0.43(Predicted)
color 
yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17248
Product name
Thyroid Hormone Receptor Antagonist (1-850)
Purity
≥98%
Packaging
1mg
Price
$45
Updated
2024/03/01
Cayman Chemical
Product number
17248
Product name
Thyroid Hormone Receptor Antagonist (1-850)
Purity
≥98%
Packaging
5mg
Price
$177
Updated
2024/03/01
Cayman Chemical
Product number
17248
Product name
Thyroid Hormone Receptor Antagonist (1-850)
Purity
≥98%
Packaging
10mg
Price
$330
Updated
2024/03/01
ApexBio Technology
Product number
C3006
Product name
ThyroidHormoneReceptorAntagonist(1-850)
Packaging
10mg
Price
$374
Updated
2021/12/16
AK Scientific
Product number
5393CH
Product name
ThyroidHormoneReceptorAntagonist,1-850
Packaging
10mg
Price
$464
Updated
2021/12/16
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THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 Chemical Properties,Usage,Production

Description

The activity of the thyroid hormones, L-thyroxine (T4; ) and 3,3'',5-triiodo-L-thyronine (T3; ), is mediated by thyroid hormone nuclear receptors TRα and TRβ. Gene knockout studies in mice indicate that TRα modulates the effect of thyroid hormone on calorigenesis and on the cardiovascular system, while TRβ plays a role in the development of the auditory system and in the negative feedback of thyroid stimulating hormone by T3 in the pituitary. Thyroid hormone receptor antagonist (1-850) competitively blocks T3 binding to both TRα and TRβ (IC50s = 1.5 μM), demonstrating ~1,000-fold lower affinity for TRα in intact cells compared with T3. This compound is specific, showing no effect on the activity of the related retinoic acid receptor α.

target

thyroid hormone receptor

IC 50

1.5 μm

References

[1] schapira m, raaka b m, das s, et al. discovery of diverse thyroid hormone receptor antagonists by high-throughput docking[j]. proceedings of the national academy of sciences of the united states of america, 2003, 100(12): 7354-7359.

THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 Preparation Products And Raw materials

Raw materials

Preparation Products

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THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 Suppliers

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251310-57-3, THYROID HORMONE RECEPTOR ANTAGONIST, 1-850Related Search:

Thyroid Transcription Factor 1 (TTF-1) (D2E8) Rabbit mAb

  • THYROID HORMONE RECEPTOR ANTAGONIST, 1-850
  • TR ANTAGONIST 1-850
  • 2-(2-(-(4-NITROPHENYL)-4-PIPERIDINYLIDENE)ACETYL)-N-(3-(TRIFLUOROMETHYL) PHENYL)-1-HYDRAZINE CARBOXAMIDE
  • 1-[[2-[1-(4-nitrophenyl)piperidin-4-ylidene]acetyl]amino]-3-[3-(trifluoromethyl)phenyl]urea
  • Acetic acid, 2-[1-(4-nitrophenyl)-4-piperidinylidene]-, 2-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]hydrazide
  • 251310-57-3
  • C21H20F3N5O4