ChemicalBook > CAS DataBase List > Chemerin-9 (149-157)

Chemerin-9 (149-157)

Product Name: Chemerin-9 (149-157)
CAS No.: 676367-27-4
Chemical Name: Chemerin-9 (149-157)
Synonyms: Chemerin-9;Chemerin-9 (149-157);L-Serine, L-tyrosyl-L-phenylalanyl-L-prolylglycyl-L-glutaminyl-L-phenylalanyl-L-alanyl-L-phenylalanyl-
CBNumber: CB84713669
Molecular Formula: C54H66N10O13
Formula Weight: 1063.16
MOL File: 676367-27-4.mol

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Chemerin-9 (149-157) Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
Water Solubility: Soluble to 1 mg/ml in water

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Hazard and Precautionary Statements (GHS)

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Chemerin-9 (149-157) Chemical Properties,Usage,Production

Description

Chemerin-9 (149-157), the nonapeptide (149)YFPGQFAFS(157) (chemerin-9), corresponding to the C terminus of processed chemerin, retains most of the activity of the full-size protein, with regard to agonism toward the chemerinR[1].

Uses

Chemerin-9 (149-157) is a potent agonist of chemokine-like receptor 1 (CMKLR1) . Chemerin-9 (149-157) has anti-inflammatory activity. Chemerin-9 (149-157) stimulates phosphorylation of Akt and ERK as well as ROS production. Chemerin-9 (149-157) ameliorates Aβ1-42-induced memory impairmen. Chemerin-9 (149-157) regulates immune responses, adipocyte differentiation, and glucose metabolism[1][2][3][4].

in vivo

Chemerin-9 (149-157) (0.2 mg/kg; i.p.; daily, for 42 days) alleviates glucose intolerance and IR in PDM mice^[1].
Chemerin-9 (149-157) (7.7? μg /kg; i.h.; daily, for 28 days) has anti-inflammatory and anti-angiogenic effects in ApoE^{-/-^{mice and protects the abdominal aorta from MMP damage^[2].

Chemerin-9 (149-157) (8 μg/kg; ICV; daily; for 14 d; male Kunming mice) ameliorates Aβ_1-42-induced memory impairment^[3].}}

Animal Model:	PDM mice^[1]
Dosage:	0.2 mg/kg
Administration:	Intraperitoneal injection; daily, for 42 days
Result:	Increased expression of chemerin, GLUT2, and PDX1, which led to the alleviation of glucose intolerance and IR in PDM model mice.

Animal Model:	ApoE^{-/-^{mice^[2]}}
Dosage:	7.7 μg /kg
Administration:	Subcutaneous injection; daily, for 28 days
Result:	Suppressed the enlargement of abdominal aorta and reversed the SMC loss.

Animal Model:	ApoE^{-/-^{mice^[2]}}
Dosage:	7.7 μg /kg
Administration:	Subcutaneous injection; daily, for 28 days
Result:	Down-regulated MMP2 and MMP-9 expression and decreased the levels of chemerin and CMKLR1.

Animal Model:	Male Kunming mice^[3]
Dosage:	8 μg/kg
Administration:	Intracerebroventrical injection; daily; for 14 days
Result:	Increased in the levels of pro-in?ammatory cytokines such as interleukin-1β (IL-1β), tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) in the hippocampus.

storage

Store at -20°C

References

[1]. Wittamer V, et al. The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency. J Biol Chem. 2004 Mar 12;279(11):9956-62.

Chemerin-9 (149-157) Preparation Products And Raw materials

Raw materials

Preparation Products

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676367-27-4, Chemerin-9 (149-157)Related Search:

Chemerin-9 (149-157)

L-Serine, L-tyrosyl-L-phenylalanyl-L-prolylglycyl-L-glutaminyl-L-phenylalanyl-L-alanyl-L-phenylalanyl-

Chemerin-9

676367-27-4

C54H66N10O13