NSC49652

Product Name: NSC49652
CAS No.: 908563-68-8
Chemical Name: NSC49652
Synonyms: NSC49652;NSC49652, 10 mM in DMSO;(2E)-1-(2-Hydroxyphenyl)-3-(3-pyridinyl)-2-propenone;(2E)-1-(2-hydroxyphenyl)-3-(pyridin-3-yl)prop-2-en-1-one;2-Propen-1-one, 1-(2-hydroxyphenyl)-3-(3-pyridinyl)-, (2E)-
CBNumber: CB84718644
Molecular Formula: C14H11NO2
Formula Weight: 225.24
MOL File: 908563-68-8.mol

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NSC49652 Property

Boiling point:: 414.3±45.0 °C(Predicted)
Density: 1.241±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 20.83 mg/mL (92.48 mM)
pka: 7.68±0.30(Predicted)
form: Solid
color: Light yellow to yellow
InChI: 1S/C14H11NO2/c16-13-6-2-1-5-12(13)14(17)8-7-11-4-3-9-15-10-11/h1-10,16H/b8-7+
InChIKey: CRWNZUBUBIULHB-BQYQJAHWSA-N
SMILES: OC1=CC=CC=C1C(/C=C/C2=CN=CC=C2)=O

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Safety

WGK Germany: WGK 3
HS Code: 2914310000
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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NSC49652 Chemical Properties,Usage,Production

Uses

(2E)-1-(2-Hydroxyphenyl)-3-(3-pyridinyl)-2-propenone is used in the synthesis of 2,4,6-Trisubstituted Pyrimidines.

Biological Activity

NSC49652 is a orally active, potent and selective inhibitor of death receptor p75NTR (p75 neurotrophin receptor) th at targets the interfaces between transmembrane domains (TMDs). NSC49652 induces profound conformational changes and triggers p75NTR dependent cancer cell death. It inhibits the growth of cancer in melanoma mouse model.

NSC49652 Preparation Products And Raw materials

Raw materials

Preparation Products

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NSC49652 Suppliers

China 14 United States 1 Global 15

Shanghai EFE Biological Technology Co., Ltd.

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908563-68-8, NSC49652Related Search:

NSC49652

(2E)-1-(2-hydroxyphenyl)-3-(pyridin-3-yl)prop-2-en-1-one

2-Propen-1-one, 1-(2-hydroxyphenyl)-3-(3-pyridinyl)-, (2E)-

(2E)-1-(2-Hydroxyphenyl)-3-(3-pyridinyl)-2-propenone

NSC49652, 10 mM in DMSO

908563-68-8