NSC49652 Property

Boiling point:

414.3±45.0 °C(Predicted)

Density 

1.241±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO : ≥ 20.83 mg/mL (92.48 mM)

pka

7.68±0.30(Predicted)

form 

Solid

color 

Light yellow to yellow

Safety

HS Code 

2914310000

Hazard and Precautionary Statements (GHS)

NSC49652 Chemical Properties,Usage,Production

Uses

(2E)-1-(2-Hydroxyphenyl)-3-(3-pyridinyl)-2-propenone is used in the synthesis of 2,4,6-Trisubstituted Pyrimidines.

Biological Activity

NSC49652 is a orally active, potent and selective inhibitor of death receptor p75NTR (p75 neurotrophin receptor) th at targets the interfaces between transmembrane domains (TMDs). NSC49652 induces profound conformational changes and triggers p75NTR dependent cancer cell death. It inhibits the growth of cancer in melanoma mouse model.