BETd-246

Product Name: BETd-246
CAS No.: 2140289-17-2
Chemical Name: BETd-246
Synonyms: BETd-246;BETd-246 (BETd 246;4-[(3-Cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-4-isoxazolyl)-N-[3-[2-[2-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]propoxy]ethoxy]ethoxy]propyl]-6-methoxy-9H-pyrimido[4,5-b]indole-2-carboxamide;9H-Pyrimido[4,5-b]indole-2-carboxamide, 4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-4-isoxazolyl)-N-[3-[2-[2-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]propoxy]ethoxy]ethoxy]propyl]-6-methoxy-;4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)-N-(3-{2-[2-(3-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}propoxy)ethoxy]ethoxy}propyl)-6-methoxy-9H-pyrimido[4,5-b]indole-2-carboxamide
CBNumber: CB84718705
Molecular Formula: C48H55N11O10
Formula Weight: 946.02
MOL File: 2140289-17-2.mol

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BETd-246 Property

Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C, stored under nitrogen
solubility: DMSO : 200 mg/mL (211.41 mM; Need ultrasonic)
form: Solid
pka: 10.75±0.40(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0087862
Product name: BETd-246
Purity: 98.03%
Packaging: 5mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0087862
Product name: BETd-246
Purity: 98.03%
Packaging: 10mg
Price: $950
Updated: 2021/12/16

ChemScene

Product number: CS-0087862
Product name: BETd-246
Purity: 98.03%
Packaging: 25mg
Price: $1950
Updated: 2021/12/16

ChemScene

Product number: CS-0087862
Product name: BETd-246
Purity: 98.03%
Packaging: 50mg
Price: $2950
Updated: 2021/12/16

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BETd-246 Chemical Properties,Usage,Production

Uses

BETd-246 is a second-generation and PROTAC-based BET bromodomain (BRD) inhibitor connected by ligands for Cereblon and BET, exhibiting superior selectivity, potency and antitumor activity[1].

in vivo

BETd-246 (5 mg/kg, IV, 3 times per week for 3 weeks) treatment effectively inhibits WHIM24 tumor growth, similar to the antitumor activity of BETi-211 with higher dosage and more frequently administration. The treatment of 10 mg/kg induces partial tumor regression during treatment without apparent toxicity. BETd-246 has very limited drug exposure in the xenograft tumor tissue in MDA-M-231and MDA-MB-468 models^[1].

Animal Model:	“Washington Human in Mouse (WHIM)” (PDX) model developed from a patient with treatment-resistant breast cancer (ESR^E380Q, PR- and HER2-))^[1].
Dosage:	5, 10 mg/kg
Administration:	IV, 3 times per week for 3 weeks.
Result:	Effectively inhibited WHIM24 tumor growth.

References

[1] Bai L, et al. Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer. Cancer Res. 2017 May 1;77(9):2476-2487. DOI:10.1158/0008-5472.CAN-16-2622

BETd-246 Preparation Products And Raw materials

Raw materials

Preparation Products

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BETd-246 Suppliers

China 20 United States 3 Global 23

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
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Email: 3003855609@qq.com
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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
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Shanghai finete Pharmaceutical Co., Ltd.

Tel: 021-021-00000000 18221039705
Fax: QQ:17263424
Email: finetechpharm@126.com
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Fan De(Beijing) Biotechnology Co., Ltd.

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Email: liming@bio-fount.com
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Jilin Province Woda Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Country: United States
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InvivoChem

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Fax: 708-557-7486
Email: sales@invivochem.cn
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Wuhan Fortuna Chemical Co., Ltd

Tel: +86-027-59207850 +86-13986145403;
Fax: 86-27-59524646
Email: info@fortunachem.com
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
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ShenZhen Trendseen Biological Technology Co.,Ltd.

Tel: 13417589054
Email: trendseenbio@gmail.com
Country: China
ProdList: 9069
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View Lastest Price from BETd-246 manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: BETd-246 2140289-17-2
Price: US $0.00/mg
Min. Order: 1mg
Purity: 98%min
Supply Ability: 50mg
Release date: 2021-08-26

2140289-17-2, BETd-246Related Search:

BETd-246

BETd-246 (BETd 246

9H-Pyrimido[4,5-b]indole-2-carboxamide, 4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-4-isoxazolyl)-N-[3-[2-[2-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]propoxy]ethoxy]ethoxy]propyl]-6-methoxy-

4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)-N-(3-{2-[2-(3-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}propoxy)ethoxy]ethoxy}propyl)-6-methoxy-9H-pyrimido[4,5-b]indole-2-carboxamide

4-[(3-Cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-4-isoxazolyl)-N-[3-[2-[2-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]propoxy]ethoxy]ethoxy]propyl]-6-methoxy-9H-pyrimido[4,5-b]indole-2-carboxamide

2140289-17-2

C48H55N11O10