ChemicalBook > CAS DataBase List > CP-105,696

CP-105,696

Product Name
CP-105,696
CAS No.
158081-99-3
Chemical Name
CP-105,696
Synonyms
CP-105,696;Pfizer 105696;UNII-Z7354TW4BM;CP105696,CP 105696;CP-105,696 >=98% (HPLC);CP105696 (Pfizer 105696);CP 105696; CP105696; CP-105696; UNII-Z7354TW4BM; PFIZER 105696;1-((3S,4R)-3-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentanecarboxylic acid;1-((3S,4R)-3-([1,1'-Biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentanecarboxylic acid;1-((3S,4R)-3-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentane-1-carboxylic acid
CBNumber
CB84741785
Molecular Formula
C28H28O4
Formula Weight
428.52
MOL File
158081-99-3.mol
More
Less

CP-105,696 Property

Boiling point:
651.2±55.0 °C(Predicted)
Density 
1.252±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
Soluble in DMSO
form 
powder
pka
4.35±0.20(Predicted)
color 
white to beige
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0363
Product name
CP-105,696
Purity
≥98% (HPLC)
Packaging
5MG
Price
$164
Updated
2023/06/20
Sigma-Aldrich
Product number
PZ0363
Product name
CP-105,696
Purity
≥98% (HPLC)
Packaging
25MG
Price
$508
Updated
2023/06/20
ChemScene
Product number
CS-0014935
Product name
CP-105696
Purity
≥98.0%
Packaging
5mg
Price
$290
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573184
Product name
CP 105696
Purity
>98%
Packaging
100mg
Price
$1431.4
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573184
Product name
CP 105696
Purity
>98%
Packaging
250mg
Price
$2541.5
Updated
2021/12/16
More
Less

CP-105,696 Chemical Properties,Usage,Production

Uses

CP-105,696 has been used as a leukotriene B4 receptor (LTB4R) antagonist to study the influence of the LTB4 pathway in the pathogenesis of acute itch flares in irritant calcipotriol (MC903)+ model allergen ovalbumin (OVA) sensitized murine model of atopic dermatitis (AD)-like disease.

Biochem/physiol Actions

CP-105,696 is an orally active, potent and selective leukotriene B4 receptor (LTB4R) antagonist (IC50 against [3H]LTB4 = 5.6 nM for binding human neutrophils; IC50 = 9.7 nM & 30.3 nM, respectively using guinea pig spleen or mouse membranes) that targets LTB4R high- and low-affinity binding sites in a LTB4 non-competitive and competitive manner, respectively. CP-105,696 inhibits 5 nM LTB4-induced human neutrophils chemotaxis and CDllb upregualtion (IC50 = 5.2 nM and 430 nM, respectively) without inhibiting cyclooxygenase activity or affecting chemotaxis induced by C5a, PAF, IL-8. Oral administration is efficacious against intradermal LTB4 (100 ng/mouse), but not IL-1, injection-induced neutrophil accumulation in mice and guinea pigs (ED50 = 4.2 and 0.26 mgkg, respectively). CP-105,696 in vivo efficacy is also demonstrated in other animal models, including collagen-induced arthritis (CIA; 0.3-10 mg/kg in mice), allergic encephalomyelitis (ED50= 8.6 mg/kg; mice), and asthma (10-30 mg/kg; primate).

CP-105,696 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

CP-105,696 Suppliers

China 29 Japan 1 United States 3 Global 33
Sigma-Aldrich Japan K.K.
Tel
--
Fax
--
Email
sialjp@sial.com
Country
Japan
ProdList
5753
Advantage
58

158081-99-3, CP-105,696Related Search:


  • CP-105,696
  • 1-[(3S,4R)-4-hydroxy-3-[(4-phenylphenyl)methyl]-3,4-dihydro-2H-chromen-7-yl]cyclopentane-1-carboxylic acid
  • 1-((3S,4R)-3-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentane-1-carboxylic acid
  • CP 105696; CP105696; CP-105696; UNII-Z7354TW4BM; PFIZER 105696
  • Pfizer 105696
  • UNII-Z7354TW4BM
  • Cyclopentanecarboxylic acid, 1-[(3S,4R)-3-([1,1'-biphenyl]-4-ylmethyl)-3,4-dihydro-4-hydroxy-2H-1-benzopyran-7-yl]-
  • CP-105,696 >=98% (HPLC)
  • CP105696 (Pfizer 105696)
  • CP105696,CP 105696
  • 1-((3S,4R)-3-([1,1'-biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentanecarboxylic acid
  • 1-((3S,4R)-3-([1,1'-Biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentanecarboxylic acid
  • 1-((3S,4R)-3-([1,1'-Biphenyl]-4-ylmethyl)-4-hydroxychroman-7-yl)cyclopentane-1-carboxylic acid
  • 1-[(3S,4R)-3-({[1,1'-biphenyl]-4-yl}methyl)-4-hydroxy-3,4-dihydro-2H-1-benzopyran-7-yl]cyclopentane-1-carboxylic acid
  • 158081-99-3
  • API