Rimegepant sulfate
- Product Name
- Rimegepant sulfate
- CAS No.
- 1374024-48-2
- Chemical Name
- Rimegepant sulfate
- Synonyms
- RIMEGEPANT SULFATE;Rimegepant sulfate hydrate;Rimegepant sulfate，PhEur/USP(DMF);Rimegepant 1/2Sulfate 3/2Trihydrate;Rimegepant hemisulfate sesquihydrate;[(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl]4-(2-oxo-3H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate;(5S,6S,9R)-5-amino-6-(2,3difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b] pyridin-9-yl4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)-1-piperidinecarboxylate hemisulfate sesquihydrate;(5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate hemisulfate sesquihydrate;Rimegepant sulfate hydrate【Chemical name：1-Piperidinecarboxylic acid, 4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-, (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta;Rimegepant sulfate hydrate【Chemical name：1-Piperidinecarboxylic acid, 4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-, (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl ester, sulfate, hydrate (2:1:3)】
- CBNumber
- CB84748603
- Molecular Formula
- C28H30F2N6O7S
- Formula Weight
- 632.64
- MOL File
- 1374024-48-2.mol
Rimegepant sulfate Property
- InChI
- InChI=1/C28H28F2N6O3.H2O4S/c29-20-6-1-4-17(23(20)30)18-8-9-22(25-19(24(18)31)5-2-12-32-25)39-28(38)35-14-10-16(11-15-35)36-21-7-3-13-33-26(21)34-27(36)37;1-5(2,3)4/h1-7,12-13,16,18,22,24H,8-11,14-15,31H2,(H,33,34,37);(H2,1,2,3,4)/t18-,22+,24-;/s3
- InChIKey
- SBWRYPRKGHWPOH-FDZFFRPLNA-N
- SMILES
- S(O)(O)(=O)=O.O=C1NC2=NC=CC=C2N1C1CCN(C(=O)O[C@@H]2CC[C@@H](C3C=CC=C(F)C=3F)[C@H](N)C3=CC=CN=C23)CC1 |&1:22,25,34,r|
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P314Get medical advice/attention if you feel unwell.
P501Dispose of contents/container to..…
Rimegepant sulfate Chemical Properties,Usage,Production
Description
Rimegepant sulfate is a small molecule, highly selective calcitonin gene-related peptide antagonist (CGRP) developed by Biohaven Pharmaceutical Holdings, Inc. and approved by the FDA for the acute treatment of migraine. rimegepant and ubrogepant are the only CGRP antagonists with oral bioavailability. Because of the absence of vasoconstrictive properties observed with oral CGRP antagonists, the use of rimegepant is safer and more reliable in patients with contraindications to standard therapy[1].
Uses
Rimegepant sulfate is indicated for the acute treatment of migraine and for the preventive treatment of episodic migraine in adults.
Trade name
Nurtec
Mechanism of action
Remegipam sulfate is used for the acute treatment of migraine by antagonizing CGRP receptors, reducing CGRP-induced vasodilation and pain signal transmission.
Side effects
Common side effects of Rimegepant sulfate are nausea, which may be severe enough to cause shortness of breath, difficulty breathing; swelling of the face, eyes, mouth, throat, tongue, or lips; rash, measles; and itching.
Synthesis
Rimegepant sulfate is prepared by the reaction of rimegepant and water.
Step: With sulfuric acid In ethanol at 20 - 70℃; Solvent; Temperature.
References
[1] J S. Rimegepant: First Approval.[J]. Drugs, 2020, 80 7: 741-746. DOI:10.1007/s40265-020-01301-3.
Rimegepant sulfate Preparation Products And Raw materials
Raw materials
Preparation Products
Rimegepant sulfate Suppliers
- Tel
- 028-13350092412 13350092412
- pany01@creditpharma.com
- Country
- China
- ProdList
- 10
- Advantage
- 58
- Tel
- +86-0576--88902229 +86-13968687450
- yuxin@yuxchem.com
- Country
- China
- ProdList
- 265
- Advantage
- 58
- Tel
- 025-58741518 13327700685
- sales@vcarepharmatech.com
- Country
- China
- ProdList
- 495
- Advantage
- 58
- Tel
- 028-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 7218
- Advantage
- 58
- Tel
- 519-88821493 18915891730
- shm@czpharma.com
- Country
- China
- ProdList
- 170
- Advantage
- 58
- Tel
- 021-68187180 13681683526
- Fax
- 021-68187179
- lchen@syncozymes.com
- Country
- China
- ProdList
- 317
- Advantage
- 55
- Tel
- -1345456643 15315114555
- Fax
- QQ:1345456643
- 1345456643@qq.com
- Country
- China
- ProdList
- 243
- Advantage
- 58
- Tel
- 029-81310890 18165209495
- 2929288192@qq.com
- Country
- China
- ProdList
- 9729
- Advantage
- 58
- Tel
- 0531-82371986 15269101859
- Fax
- 0531-82375893
- 3276840968@qq.com
- Country
- China
- ProdList
- 1604
- Advantage
- 58
- Tel
- 15867635987
- jasonhu09@163.com
- Country
- China
- ProdList
- 796
- Advantage
- 58
View Lastest Price from Rimegepant sulfate manufacturers
- Product
- Rimegepant sulfate，PhEur/USP(DMF) 1374024-48-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2025-08-05
- Product
- Rimegepant sulfate 1374024-48-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-06-02
- Product
- Rimegepant sulfate 1374024-48-2
- Price
- US $5.00-0.50/KG
- Min. Order
- 1KG
- Purity
- 99% hplc
- Supply Ability
- 500TONS
- Release date
- 2025-05-30