KRN5

Product Name: KRN5
CAS No.: 1800465-47-7
Chemical Name: KRN5
Synonyms: KRN5;KRN5,KRN-5;KRN5, 10 mM in DMSO;13-(2-Fluorobenzyl)-9,10-dimethoxy-5,6-dihydro-8H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-8-one;8H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizin-8-one, 13-[(2-fluorophenyl)methyl]-5,6-dihydro-9,10-dimethoxy-
CBNumber: CB84796664
Molecular Formula: C27H22FNO5
Formula Weight: 459.47
MOL File: 1800465-47-7.mol

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KRN5 Property

Boiling point:: 682.0±55.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 6 mg/mL (13.06 mM);Water : < 0.1 mg/mL (insoluble)
form: Solid
pka: -1.93±0.40(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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KRN5 Chemical Properties,Usage,Production

Uses

KRN5, a derivative of KRN2, is an oral active Nuclear factor of activated T cells 5 (NFAT5) suppressor, with an IC50 of 750 nM. KRN5 has potential to treat NFAT5-mediated Chronic Arthritis[1].

in vivo

Oral feeding of KRN5 (15 mg/kg and 60 mg/kg) every other day for 3 weeks from day 21 dose-dependently mitigates arthritis severity^[1].
The concentration of serum anti-type II collagen IgG also significantly decreases in the sera of KRN5-treated mice. TNF-α and IL-6 production by LPS-stimulated splenocytes are significantly lower in KRN5-treated CIA mice than in vehicle-treated mice^[1].

Animal Model:	8-week-old DBA/1Jmice immunized with bovine type II collagen^[1].
Dosage:	15 mg/kg and 60 mg/kg.
Administration:	Orally on alternate days (every other day) for 3 weeks.
Result:	Dose-dependently mitigated arthritis severity.

References

[1] Han EJ, et al. Suppression of NFAT5-mediated Inflammation and Chronic Arthritis by Novel κB-binding Inhibitors. EBioMedicine. 2017 Apr;18:261-273. DOI:10.1016/j.ebiom.2017.03.039

KRN5 Preparation Products And Raw materials

Raw materials

Preparation Products

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KRN5 Suppliers

China 14 United States 3 Global 17

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

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TargetMol Chemicals Inc.

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1800465-47-7, KRN5Related Search:

KRN5

8H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizin-8-one, 13-[(2-fluorophenyl)methyl]-5,6-dihydro-9,10-dimethoxy-

KRN5,KRN-5

13-(2-Fluorobenzyl)-9,10-dimethoxy-5,6-dihydro-8H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-8-one

KRN5, 10 mM in DMSO

1800465-47-7