MZP-55

Product Name: MZP-55
CAS No.: 2010159-48-3
Chemical Name: MZP-55
Synonyms: MZP-55;(2S,4R)-1-[(2S)-2-[14-({4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl]phenyl}formamido)-3,6,9,12-tetraoxatetradecanamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide;(2S,4R)-1-[(2S)-2-[[2-[2-[2-[2-[2-[[4-[(2S,4R)-1-acetyl-4-(4-chloroanilino)-2-methyl-3,4-dihydro-2H-quinolin-6-yl]benzoyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
CBNumber: CB84797085
Molecular Formula: C57H70ClN7O10S
Formula Weight: 1080.74
MOL File: 2010159-48-3.mol

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MZP-55 Property

Boiling point:: 1235.6±65.0 °C(Predicted)
Density: 1.268±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 50 mg/mL (46.27 mM)
form: Solid
pka: 13.54±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0045308
Product name: MZP-55
Purity: 99.75%
Packaging: 5mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0045308
Product name: MZP-55
Purity: 99.75%
Packaging: 10mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0045308
Product name: MZP-55
Purity: 99.75%
Packaging: 25mg
Price: $1600
Updated: 2021/12/16

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MZP-55 Chemical Properties,Usage,Production

Description

MZP-55 is a BET protein degrader.

Uses

MZP-55 is a PROTAC connected by ligands for von Hippel-Lindau and BRD3/4, with a Kd of 8 nM for Brd4BD2.

References

[1] Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513. DOI:10.1021/acs.jmedchem.6b01912

MZP-55 Preparation Products And Raw materials

Raw materials

Preparation Products

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MZP-55 Suppliers

China 14 United States 1 Global 15

Sichuan Wei Keqi Biological Technology Co., Ltd.

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Fan De(Beijing) Biotechnology Co., Ltd.

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Jilin Province Woda Biotechnology Co., Ltd.

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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ShenZhen Trendseen Biological Technology Co.,Ltd.

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Shanghai Easy CDMO Co.,Ltd

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Hubei Chuchang Chemical Co., Ltd

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Jilin Chinese Academy of Sciences-yanshen Technology

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RD International Technology Co., Limited

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TargetMol Chemicals Inc.

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Biosynth Biological Technology (Suzhou) Co Ltd

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Adooq Bioscience LLC

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Absin Bioscience Inc.

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Shanghai Hao Zhun Biological Technology Co., Ltd.

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2010159-48-3, MZP-55Related Search:

MZP-55

(2S,4R)-1-[(2S)-2-[[2-[2-[2-[2-[2-[[4-[(2S,4R)-1-acetyl-4-(4-chloroanilino)-2-methyl-3,4-dihydro-2H-quinolin-6-yl]benzoyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide

(2S,4R)-1-[(2S)-2-[14-({4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl]phenyl}formamido)-3,6,9,12-tetraoxatetradecanamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

2010159-48-3

C57H70ClN7O10S