N/aa
- Product Name
- N/aa
- CAS No.
- 1311136-84-1
- Chemical Name
- N/aa
- Synonyms
- (5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione;2,4-Imidazolidinedione, 5-ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-, (5R)-;Kv3.1b,corticolimbic circuits,inhibit,AUT 1,AUT1,dysfunction,Potassium Channel,recombinant human Kv3 channels,human recombinant,KcsA,schizophrenia,Inhibitor,AUT-1,Kv3.2a
- CBNumber
- CB84804783
- Molecular Formula
- C18H19N3O4
- Formula Weight
- 341.36
- MOL File
- 1311136-84-1.mol
N/aa Property
- storage temp.
- Store at -20°C
- solubility
- DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.59(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);87.88(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);14.65(Max Conc. mM) - form
- A crystalline solid
N-Bromosuccinimide Price
- Product number
- 28599
- Product name
- AUT1
- Packaging
- 10mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 28599
- Product name
- AUT1
- Packaging
- 100mg
- Price
- $341
- Updated
- 2024/03/01
- Product number
- 28599
- Product name
- AUT1
- Packaging
- 50mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- E678890
- Product name
- (5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione
- Packaging
- 50mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- E678890
- Product name
- (5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione
- Packaging
- 500mg
- Price
- $1470
- Updated
- 2021/12/16
N/aa Chemical Properties,Usage,Production
Description
AUT1 is a positive modulator of the voltage-gated potassium channel subtypes Kv3.1b, Kv3.2a, and Kv3.3 (EC50s = 4.7, 4.9, and 31.6 μM, respectively, in a patch-clamp assay). It is selective for Kv3.1b, Kv3.2a, and Kv3.3 over Kv1.5 and Kv7.1/minK channels but also inhibits the serotonin (5-HT) transporter, 5-HT3 receptor, and α1 subunit-containing nicotinic acetylcholine receptor (nAChR) in a panel of 26 ion channels, receptors, and transporters. AUT1 increases tetraethylammonium-induced decreases in the firing frequency and amplitude of action potentials in mouse somatosensory cortex slices when used at concentrations of 1 and 10 μM.
Uses
(5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione, is a novel modulator of Kv3 potassium channels which biological studies have shown it regulates the firing of parvalbumin-positive cortical interneurons.
N/aa Preparation Products And Raw materials
Raw materials
Preparation Products
N/aa Suppliers
- Tel
- 0551-66399836 18955197623
- sales@enlipharma.com
- Country
- China
- ProdList
- 1874
- Advantage
- 55
- Tel
- 021-52996696,15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4153
- Advantage
- 55
- Tel
- 17754423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8011
- Advantage
- 62
- Tel
- 21-31433387 15618786686
- Fax
- QQ:1369748377
- sales@rechemscience.com
- Country
- China
- ProdList
- 2990
- Advantage
- 58
- Tel
- QQ:65489617 15618227136
- Fax
- 21-5161 9052
- info@SuperLan-chem.com
- Country
- China
- ProdList
- 9756
- Advantage
- 58
- Tel
- +86-530-529 6766,+86-15666160102 15666160102
- Fax
- 0530-529 6766
- info@chuangli-chem.com
- Country
- China
- ProdList
- 875
- Advantage
- 55
- Tel
- 025-58851090 13611564524
- Fax
- (6)02557626880
- lwan@aikonchem.com
- Country
- China
- ProdList
- 15952
- Advantage
- 58
- Tel
- 400-400-1332688 18019345275
- Fax
- 400-133-2688
- amy@rhawn.cn
- Country
- China
- ProdList
- 15503
- Advantage
- 58
- Tel
- 021-58111628 15800915896
- Fax
- QQ 3285589261
- Country
- China
- ProdList
- 1988
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9730
- Advantage
- 58
- Tel
- +8615986615575
- Fax
- 0086-13651442114
- info@codchem.com
- Country
- China
- ProdList
- 20356
- Advantage
- 58
- Tel
- +86-0371-86658258 15093356674;
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30255
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9414
- Advantage
- 58
- Tel
- 0519-85788828 13775037613
- sales@chemrenpharm.com
- Country
- China
- ProdList
- 3553
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11289
- Advantage
- 58
- Tel
- +86-29-87569266 15319487004
- Fax
- 029-88380327
- 1015@dideu.com
- Country
- China
- ProdList
- 2263
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 12345678910
- Fax
- nanfengdrug@163
- nanfengdrug@163.com
- Country
- China
- ProdList
- 15323
- Advantage
- 58
- Tel
- 15342225168
- yutianchun2007@126.com
- Country
- China
- ProdList
- 10007
- Advantage
- 58
- Tel
- 13348960310 13348960310
- 3003867561@qq.com
- Country
- China
- ProdList
- 9946
- Advantage
- 58
- Tel
- 0371-0371-55153829 18003835034
- Fax
- 18003835034(微信)
- 2853979819@qq.com
- Country
- China
- ProdList
- 8740
- Advantage
- 58
- Tel
- 18964309092 18964309092
- 2769493375@qq.com
- Country
- China
- ProdList
- 2635
- Advantage
- 58
- Tel
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29778
- Advantage
- 58
- Tel
- 027-59101668 19945030958
- Fax
- 027-59101668
- 2881924765@qq.com
- Country
- China
- ProdList
- 7977
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6712
- Advantage
- 58
- Tel
- +86-027-59232304 15387063101
- 2881924050@qq.com
- Country
- China
- ProdList
- 9892
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24023
- Advantage
- 58
- Tel
- 0512-65118909 15162312715
- sales@szzxbio.com
- Country
- China
- ProdList
- 3001
- Advantage
- 58
- Tel
- 13720134139 13720134139
- orders@jknbiochem.com
- Country
- China
- ProdList
- 5223
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- customer_service@efebio.com
- Country
- China
- ProdList
- 8740
- Advantage
- 58
- Tel
- 0571-87632989
- sales@bingochem.com
- Country
- China
- ProdList
- 21673
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12007
- Advantage
- 58
- Tel
- 0731-18670069958 18670069958
- 184792226@qq.com
- Country
- China
- ProdList
- 3007
- Advantage
- 58
- Tel
- 18024082417
- market@ubiochem.com
- Country
- China
- ProdList
- 9180
- Advantage
- 58
- Tel
- +86-371-66670886
- info@dakenam.com
- Country
- China
- ProdList
- 15957
- Advantage
- 58
- Tel
- +8613720134139
- orders@jknbiochem.com
- Country
- China
- ProdList
- 4604
- Advantage
- 58
- Tel
- +86-852-30606658
- market18@leapchem.com
- Country
- China
- ProdList
- 24738
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6846
- Advantage
- 58