N/aa

ChemicalBook > CAS DataBase List > N/aa

Product Name: N/aa
CAS No.: 1311136-84-1
Chemical Name: N/aa
Synonyms: (R)-5-Ethyl-3-(6-(3-methoxy-4-methylphenoxy)pyridin-3-yl)imidazolidine-2,4-dione;(5R)-5-ethyl-3-[6-(3-methoxy-4-methylphenoxy)pyridin-3-yl]imidazolidine-2,4-dione;(5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione;2,4-Imidazolidinedione, 5-ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-, (5R)-;(R)-5-Ethyl-3-(6-(3-methoxy-4-methylphenoxy)pyridin-3-yl)imidazolidine-2,4-dione , AUT1;Kv3.1b,corticolimbic circuits,inhibit,AUT 1,AUT1,dysfunction,Potassium Channel,recombinant human Kv3 channels,human recombinant,KcsA,schizophrenia,Inhibitor,AUT-1,Kv3.2a
CBNumber: CB84804783
Molecular Formula: C18H19N3O4
Formula Weight: 341.36
MOL File: 1311136-84-1.mol

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N/aa Property

storage temp.: Store at -20°C
solubility: DMSO:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.59(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);87.88(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);14.65(Max Conc. mM)
form: A crystalline solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28599
Product name: AUT1
Packaging: 10mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 28599
Product name: AUT1
Packaging: 100mg
Price: $341
Updated: 2024/03/01

Cayman Chemical

Product number: 28599
Product name: AUT1
Packaging: 50mg
Price: $193
Updated: 2024/03/01

TRC

Product number: E678890
Product name: (5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione
Packaging: 50mg
Price: $185
Updated: 2021/12/16

TRC

Product number: E678890
Product name: (5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione
Packaging: 500mg
Price: $1470
Updated: 2021/12/16

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N/aa Chemical Properties,Usage,Production

Description

AUT1 is a positive modulator of the voltage-gated potassium channel subtypes K_v3.1b, K_v3.2a, and K_v3.3 (EC₅₀s = 4.7, 4.9, and 31.6 μM, respectively, in a patch-clamp assay). It is selective for K_v3.1b, K_v3.2a, and K_v3.3 over K_v1.5 and K_v7.1/minK channels but also inhibits the serotonin (5-HT) transporter, 5-HT₃ receptor, and α1 subunit-containing nicotinic acetylcholine receptor (nAChR) in a panel of 26 ion channels, receptors, and transporters. AUT1 increases tetraethylammonium-induced decreases in the firing frequency and amplitude of action potentials in mouse somatosensory cortex slices when used at concentrations of 1 and 10 μM.

Uses

(5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione, is a novel modulator of Kv3 potassium channels which biological studies have shown it regulates the firing of parvalbumin-positive cortical interneurons.

N/aa Preparation Products And Raw materials

Raw materials

Preparation Products

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1311136-84-1, N/aaRelated Search:

2,4-Imidazolidinedione, 5-ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-, (5R)-

(5R)-5-Ethyl-3-[6-(3-methoxy-4-methylphenoxy)-3-pyridinyl]-2,4-imidazolidinedione

Kv3.1b,corticolimbic circuits,inhibit,AUT 1,AUT1,dysfunction,Potassium Channel,recombinant human Kv3 channels,human recombinant,KcsA,schizophrenia,Inhibitor,AUT-1,Kv3.2a

(R)-5-Ethyl-3-(6-(3-methoxy-4-methylphenoxy)pyridin-3-yl)imidazolidine-2,4-dione

(5R)-5-ethyl-3-[6-(3-methoxy-4-methylphenoxy)pyridin-3-yl]imidazolidine-2,4-dione

(R)-5-Ethyl-3-(6-(3-methoxy-4-methylphenoxy)pyridin-3-yl)imidazolidine-2,4-dione , AUT1

1311136-84-1