VX-659

Product Name: VX-659
CAS No.: 2204245-48-5
Chemical Name: VX-659
Synonyms: VX-659;BAMOCAFTOR;Bamocaftor, 10 mM in DMSO;(S)-N-(phenylsulfonyl)-6-(3-(2-(1-(trifluoromethyl)cyclopropyl)ethoxy)-1H-pyrazol-1-yl)-2-(2,2,4-trimethylpyrrolidin-1-yl)nicotinamide;N-(benzenesulfonyl)-6-[3-[2-[1-(trifluoromethyl)cyclopropyl]ethoxy]pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide;3-Pyridinecarboxamide, N-(phenylsulfonyl)-6-[3-[2-[1-(trifluoromethyl)cyclopropyl]ethoxy]-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethyl-1-pyrrolidinyl]-
CBNumber: CB84806095
Molecular Formula: C28H32F3N5O4S
Formula Weight: 591.65
MOL File: 2204245-48-5.mol

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VX-659 Property

Density: 1.40±0.1 g/cm3(Predicted)
pka: 3.96±0.10(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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VX-659 Chemical Properties,Usage,Production

Uses

Bamocaftor (VX-659) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore F508del-CFTR protein function. Bamocaftor can be used combine with Tezacaftor (HY-15448) and Ivacaftor (HY-13017) in cystic fibrosis research[1].

References

[1] Ghelani DP, et al. Emerging Cystic Fibrosis Transmembrane Conductance Regulator Modulators as New Drugs for Cystic Fibrosis: A Portrait of in Vitro Pharmacology and Clinical Translation. DOI:10.1021/acsptsci.9b00060

VX-659 Preparation Products And Raw materials

Raw materials

Preparation Products

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VX-659 Suppliers

China 11 United States 2 Global 13

Beijing xinyanhui pharmaceutical research and development co., LTD

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Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

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TargetMol Chemicals Inc.

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Shanghai Tachizaki Biomedical Research Center

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Sangon Biotech (Shanghai) Co.,Ltd.

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Henan Tianfu Chemical Co.,Ltd.

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2204245-48-5, VX-659Related Search:

VX-659

BAMOCAFTOR

N-(benzenesulfonyl)-6-[3-[2-[1-(trifluoromethyl)cyclopropyl]ethoxy]pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide

(S)-N-(phenylsulfonyl)-6-(3-(2-(1-(trifluoromethyl)cyclopropyl)ethoxy)-1H-pyrazol-1-yl)-2-(2,2,4-trimethylpyrrolidin-1-yl)nicotinamide

3-Pyridinecarboxamide, N-(phenylsulfonyl)-6-[3-[2-[1-(trifluoromethyl)cyclopropyl]ethoxy]-1H-pyrazol-1-yl]-2-[(4S)-2,2,4-trimethyl-1-pyrrolidinyl]-

Bamocaftor, 10 mM in DMSO

2204245-48-5