ChemicalBook > CAS DataBase List > N-(trans-3-[5-[(1R)-1-hydroxyethyl]-1,3,4-oxadiazol-2-yl]cyclobutyl)-3-phenyl-1,2-oxazole-5-carboxamide

N-(trans-3-[5-[(1R)-1-hydroxyethyl]-1,3,4-oxadiazol-2-yl]cyclobutyl)-3-phenyl-1,2-oxazole-5-carboxamide

Product Name
N-(trans-3-[5-[(1R)-1-hydroxyethyl]-1,3,4-oxadiazol-2-yl]cyclobutyl)-3-phenyl-1,2-oxazole-5-carboxamide
CAS No.
1953130-87-4
Chemical Name
N-(trans-3-[5-[(1R)-1-hydroxyethyl]-1,3,4-oxadiazol-2-yl]cyclobutyl)-3-phenyl-1,2-oxazole-5-carboxamide
Synonyms
PTI-428;Nesolicaftor;Nesolicaftor(PTI-428);PTI-428; PTI 428; PTI428;;Nesolicaftor, 10 mM in DMSO;Nesolicaftor (PTI-428) ，S6911;5-Isoxazolecarboxamide, N-[trans-3-[5-[(1R)-1-hydroxyethyl]-1,3,4-oxadiazol-2-yl]cyclobutyl]-3-phenyl-;N-(trans-3-[5-[(1R)-1-hydroxyethyl]-1,3,4-oxadiazol-2-yl]cyclobutyl)-3-phenyl-1,2-oxazole-5-carboxamide;inhibit,CFTR,Inhibitor,PTI 428,PTI428,cystic fibrosis,Nesolicaftor,Autophagy,Cystic fibrosis transmembrane conductance regulator
CBNumber
CB84813471
Molecular Formula
C18H18N4O4
Formula Weight
354.36
MOL File
1953130-87-4.mol
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N-(trans-3-[5-[(1R)-1-hydroxyethyl]-1,3,4-oxadiazol-2-yl]cyclobutyl)-3-phenyl-1,2-oxazole-5-carboxamide Property

Density 
1.40±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 250 mg/mL (705.50 mM)
form 
Solid
pka
12.22±0.40(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0090368
Product name
PTI-428
Purity
99.77%
Packaging
5mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0090368
Product name
PTI-428
Purity
99.77%
Packaging
10mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-0090368
Product name
PTI-428
Purity
99.77%
Packaging
50mg
Price
$1200
Updated
2021/12/16
ChemScene
Product number
CS-0090368
Product name
PTI-428
Purity
99.77%
Packaging
100mg
Price
$1700
Updated
2021/12/16
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N-(trans-3-[5-[(1R)-1-hydroxyethyl]-1,3,4-oxadiazol-2-yl]cyclobutyl)-3-phenyl-1,2-oxazole-5-carboxamide Chemical Properties,Usage,Production

Uses

Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier[1].

References

[1] Mijnders M, et al. Correcting CFTR folding defects by small-molecule correctors to cure cystic fibrosis. Curr Opin Pharmacol. 2017 Jun;34:83-90. DOI:10.1016/j.coph.2017.09.014
[2] Arianna Venturini, et al. Comprehensive Analysis of Combinatorial Pharmacological Treatments to Correct Nonsense Mutations in the CFTR Gene. Int J Mol Sci. 2021 Nov 4;22(21):11972. DOI:10.3390/ijms222111972

N-(trans-3-[5-[(1R)-1-hydroxyethyl]-1,3,4-oxadiazol-2-yl]cyclobutyl)-3-phenyl-1,2-oxazole-5-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(trans-3-[5-[(1R)-1-hydroxyethyl]-1,3,4-oxadiazol-2-yl]cyclobutyl)-3-phenyl-1,2-oxazole-5-carboxamide Suppliers

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1953130-87-4, N-(trans-3-[5-[(1R)-1-hydroxyethyl]-1,3,4-oxadiazol-2-yl]cyclobutyl)-3-phenyl-1,2-oxazole-5-carboxamideRelated Search:


  • N-(trans-3-[5-[(1R)-1-hydroxyethyl]-1,3,4-oxadiazol-2-yl]cyclobutyl)-3-phenyl-1,2-oxazole-5-carboxamide
  • PTI-428
  • PTI-428; PTI 428; PTI428;
  • 5-Isoxazolecarboxamide, N-[trans-3-[5-[(1R)-1-hydroxyethyl]-1,3,4-oxadiazol-2-yl]cyclobutyl]-3-phenyl-
  • Nesolicaftor
  • Nesolicaftor(PTI-428)
  • inhibit,CFTR,Inhibitor,PTI 428,PTI428,cystic fibrosis,Nesolicaftor,Autophagy,Cystic fibrosis transmembrane conductance regulator
  • Nesolicaftor, 10 mM in DMSO
  • Nesolicaftor (PTI-428) ，S6911
  • 1953130-87-4
  • APIS