C18 Phytoceramide-d3 (t18:0/18:0-d3)
- Product Name
- C18 Phytoceramide-d3 (t18:0/18:0-d3)
- CAS No.
- 1354806-91-9
- Chemical Name
- C18 Phytoceramide-d3 (t18:0/18:0-d3)
- Synonyms
- C18 Phytoceramide-d3 (t18:0/18:0-d3);N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl]-octadecanamide-18,18,18-d3
- CBNumber
- CB84814382
- Molecular Formula
- C36H73NO4
- Formula Weight
- 583.98
- MOL File
- 1354806-91-9.mol
C18 Phytoceramide-d3 (t18:0/18:0-d3) Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- A solid
N-Bromosuccinimide Price
- Product number
- 27199
- Product name
- C18 Phytoceramide-d3 (t18:0/18:0-d3)
- Packaging
- 1mg
- Price
- $335
- Updated
- 2024/03/01
- Product number
- 27199
- Product name
- C18 Phytoceramide-d3 (t18:0/18:0-d3)
- Packaging
- 500μg
- Price
- $172
- Updated
- 2021/12/16
C18 Phytoceramide-d3 (t18:0/18:0-d3) Chemical Properties,Usage,Production
Description
C18 Phytoceramide-d3 (t18:0/18:0-d3) is intended for use as an internal standard for the quantification of C18 phytoceramide (t18:0/18:0) by GC- or LC-MS. C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in S. cerevisiae, wheat grains, and the stratum corneum layer of mammalian epidermis. Cer(t18:0/18:0) is composed of a phytosphingosine backbone amine-linked to a C18 fatty acid chain. Cer(t18:0/18:0) has a role in regulation of apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain. It also inhibits expression of the allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated murine skin tissue. Formulations containing cer(t18:0/18:0) have been used used in cosmetics as a skin protectants as they reduce water loss to prevent epidermal dehydration and irritation. [Matreya, LLC. Catalog No. 2210]
Uses
Ceramide 3-d3 (N-Stearoyl phytosphingosine-d3) is deuterium labeled Ceramide 3. C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer(t18:0/18:0) consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer(t18:0/18:0) has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue. Formulations containing cer(t18:0/18:0) have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation[1].
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
C18 Phytoceramide-d3 (t18:0/18:0-d3) Preparation Products And Raw materials
Raw materials
Preparation Products
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