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GAT228

Product Name
GAT228
CAS No.
1446648-15-2
Chemical Name
GAT228
Synonyms
GAT228;GAT228 >=98% (HPLC);3-[(1R)-2-nitro-1-phenylethyl]-2-phenyl-1H-indole;1H-Indole, 3-[(1R)-2-nitro-1-phenylethyl]-2-phenyl-
CBNumber
CB84814584
Molecular Formula
C22H18N2O2
Formula Weight
342.39
MOL File
1446648-15-2.mol
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GAT228 Property

Boiling point:
585.8±50.0 °C(Predicted)
Density 
1.237±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 20 mg/ml
form 
A solid
pka
7.77±0.18(Predicted)
color 
white to beige
optical activity
[α]/D 80 to 94°, c =1 in methanol
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24485
Product name
GAT228
Packaging
5mg
Price
$112
Updated
2024/03/01
Cayman Chemical
Product number
24485
Product name
GAT228
Packaging
10mg
Price
$207
Updated
2024/03/01
Cayman Chemical
Product number
24485
Product name
GAT228
Packaging
1mg
Price
$36
Updated
2024/03/01
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GAT228 Chemical Properties,Usage,Production

Description

GAT228 is an allosteric agonist of cannabinoid receptor 1 (CB1), the R-(+)-enantiomer of the CB1 positive allosteric modulator (PAM) GAT229 , and a component of the racemic mixture GAT211, which acts as both an agonist and PAM. GAT228 increases β-arrestin recruitment, cAMP inhibition, and ERK1/2 and PLCβ3 phosphorylation in HEK293A cells expressing GFP-tagged human CB1 (hCB1-GFP) in a concentration-dependent manner. Unlike GAT229, GAT228 has no effect on the binding of the CB receptor agonist CP 55,940 to membranes from CHO cells expressing hCB1 when used at concentrations up to 1 μM. It inhibits excitatory postsynaptic currents (EPSCs) in a subset of CB1-expressing murine autaptic hippocampal neurons when used at a concentration of 1 μM.

GAT228 Preparation Products And Raw materials

Raw materials

Preparation Products

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GAT228 Suppliers

China 7 United States 2 Global 9
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9804
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Changzhou Furuisi Biotechnology Co., Ltd
Tel
0519-85524369
Email
3477467573@qq.com
Country
China
ProdList
8617
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9266
Advantage
58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
19699
Advantage
58

1446648-15-2, GAT228Related Search:


  • GAT228
  • GAT228 >=98% (HPLC)
  • 1H-Indole, 3-[(1R)-2-nitro-1-phenylethyl]-2-phenyl-
  • 3-[(1R)-2-nitro-1-phenylethyl]-2-phenyl-1H-indole
  • 1446648-15-2