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GAT228

Product Name
GAT228
CAS No.
1446648-15-2
Chemical Name
GAT228
Synonyms
GAT228;GAT228 >=98% (HPLC);3-[(1R)-2-nitro-1-phenylethyl]-2-phenyl-1H-indole;1H-Indole, 3-[(1R)-2-nitro-1-phenylethyl]-2-phenyl-
CBNumber
CB84814584
Molecular Formula
C22H18N2O2
Formula Weight
342.39
MOL File
1446648-15-2.mol
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GAT228 Property

Boiling point:
585.8±50.0 °C(Predicted)
Density 
1.237±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 20 mg/ml
form 
A solid
pka
7.77±0.18(Predicted)
color 
white to beige
optical activity
[α]/D 80 to 94°, c =1 in methanol
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24485
Product name
GAT228
Packaging
5mg
Price
$112
Updated
2024/03/01
Cayman Chemical
Product number
24485
Product name
GAT228
Packaging
10mg
Price
$207
Updated
2024/03/01
Cayman Chemical
Product number
24485
Product name
GAT228
Packaging
1mg
Price
$36
Updated
2024/03/01
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GAT228 Chemical Properties,Usage,Production

Description

GAT228 is an allosteric agonist of cannabinoid receptor 1 (CB1), the R-(+)-enantiomer of the CB1 positive allosteric modulator (PAM) GAT229 , and a component of the racemic mixture GAT211, which acts as both an agonist and PAM. GAT228 increases β-arrestin recruitment, cAMP inhibition, and ERK1/2 and PLCβ3 phosphorylation in HEK293A cells expressing GFP-tagged human CB1 (hCB1-GFP) in a concentration-dependent manner. Unlike GAT229, GAT228 has no effect on the binding of the CB receptor agonist CP 55,940 to membranes from CHO cells expressing hCB1 when used at concentrations up to 1 μM. It inhibits excitatory postsynaptic currents (EPSCs) in a subset of CB1-expressing murine autaptic hippocampal neurons when used at a concentration of 1 μM.

GAT228 Preparation Products And Raw materials

Raw materials

Preparation Products

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GAT228 Suppliers

China 7 United States 2 Global 9
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

1446648-15-2, GAT228Related Search:


  • GAT228
  • GAT228 >=98% (HPLC)
  • 1H-Indole, 3-[(1R)-2-nitro-1-phenylethyl]-2-phenyl-
  • 3-[(1R)-2-nitro-1-phenylethyl]-2-phenyl-1H-indole
  • 1446648-15-2