ChemicalBook > CAS DataBase List > diABZI STING agonist-1 trihydrochloride

diABZI STING agonist-1 trihydrochloride

Product Name
diABZI STING agonist-1 trihydrochloride
CAS No.
2138299-34-8
Chemical Name
diABZI STING agonist-1 trihydrochloride
Synonyms
di-ABZI;STING?agonist?diABZ;diABZI STING agonist-1;diABZI STING agonist-1 3HCl;STING agonist-1 trihydrochloride;diABZI STING Agonist-1 (hydrochloride);diABZI STING Agonist 3 (hydrochloride);diABZI STING agonist-1 trihydrochloride;STING agonist-1（compound 3）trihydrochloride;inhibit,diABZI STING agonist1 trihydrochloride,MPYS,diABZI STING agonist-1 trihydrochloride,ERIS,STING,Inhibitor,MITA,Stimulator of Interferon Genes,TMEM173,diABZI STING agonist 1 trihydrochloride
CBNumber
CB84818416
Molecular Formula
C42H52ClN13O7
Formula Weight
886.41
MOL File
2138299-34-8.mol
More
Less

diABZI STING agonist-1 trihydrochloride Property

storage temp. 
Store at -20°C
solubility 
DMSO: 50 mg/ml
form 
A crystalline solid
color 
White to yellow
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
28054
Product name
diABZI STING Agonist 3 (hydrochloride)
Packaging
1mg
Price
$299
Updated
2024/03/01
Cayman Chemical
Product number
28054
Product name
diABZI STING Agonist 3 (hydrochloride)
Packaging
5mg
Price
$743
Updated
2024/03/01
Cayman Chemical
Product number
28054
Product name
diABZI STING Agonist 3 (hydrochloride)
Packaging
500μg
Price
$158
Updated
2024/03/01
TRC
Product number
A629825
Product name
1-[(2E)-4-[5-(Aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-1H-benzimidazole-5-carboxamideHydrochloride(1:3)
Packaging
1mg
Price
$360
Updated
2021/12/16
AK Scientific
Product number
1582EN
Product name
1-[(E)-4-[5-Carbamoyl-2-[(2-ethyl-5-methylpyrazole-3-carbonyl)amino]-7-(3-morpholin-4-ylpropoxy)benzimidazol-1-yl]but-2-enyl]-2-[(2-ethyl-5-methylpyrazole-3-carbonyl)amino]-7-methoxybenzimidazole-5-carboxamide;trihydrochloride
Packaging
1mg
Price
$430
Updated
2021/12/16
More
Less

diABZI STING agonist-1 trihydrochloride Chemical Properties,Usage,Production

Description

diABZI STING agonist-1 is an agonist of the stimulator of interferon genes (STING) pathway. It induces secretion of IFN-β in human peripheral blood mononuclear cells (PBMCs; EC50 = 130 nM). diABZI STING agonist-1 (2.5 mg/kg) increases serum levels of IFN-β, IL-6, TNF, and KC/GROα in wild-type, but not Sting-/-, mice. It inhibits the cytopathic effect of the common cold human coronavirus 229E (HCoV-229E) in infected MRC-5 cells (EC50 = 3 nM). diABZI STING agonist-1 also decreases the level of severe acute respiratory coronavirus 2 (SARS-CoV-2) RNA in primary human bronchial airway epithelial cells in an air-liquid interface assay. It decreases tumor volume and increases survival in a CT26 murine colorectal cancer model when administered at a dose of 3 mg/kg.

Uses

1-[(2E)-4-[5-(Aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-1H-benzimidazole-5-carboxamide Hydrochloride (1:3), an amino acid derivatve used in preparation of STING protein.

in vivo

diABZI STING agonist-1 trihydrochloride (subcutaneous injection; 2.5 mg/kg) induces STING-dependent activation of type-I interferon and pro-inflammatory cytokines in vivo[1]. diABZI STING agonist-1 trihydrochloride (intravenous injection; 3 mg/kg) exhibits systemic exposure with a half-life of 1.4 h and achieves systemic concentrations greater than the half-maximal effective concentration (EC50) for mouse STING (200 ng/ml)[1]. diABZI STING agonist-1 trihydrochloride (intravenous injection; 1.5 mg/kg; days 1, 4 and 8; 43 days) results in significant tumour growth inhibition and significantly improves survival (P < 0.001) with 8 out of 10 mice remaining tumor free at the end of the study on day 43[1].

Animal Model:Wild and Sting?/? C57Blk6 mice[1]
Dosage:2.5 mg/kg
Administration:Subcutaneous injection; 2.5 mg/kg
Result:Activated secretion of IFNβ, IL-6, TNF, and CXCL1 in wild-type but not Sting?/? mice.
Animal Model:Syngeneic mouse model of colorectal tumours (CT-26) in BALB/c mice[1]
Dosage:3 mg/kg
Administration:Intravenous injection; 3 mg/kg
Result:Exhibited a half-life of 1.4 hours and achieved systemic concentrations greater than EC50 for mouse STING (200 ng/ml).
Animal Model:Syngeneic mouse model of colorectal tumours (CT-26) in BALB/c mice[1]
Dosage:1.5 mg/kg
Administration:Intravenous injection; 1.5 mg/kg; 43 days
Result:Resulted in significant tumour growth inhibition and improved survival.

diABZI STING agonist-1 trihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

diABZI STING agonist-1 trihydrochloride Suppliers

China 47 United States 5 Global 52
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
5237
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4601
Advantage
55
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
Cool Pharm, Ltd
Tel
021-58581007 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71829
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9328
Advantage
58
Dezhou LonWel Pharmaceutical Technology Co., Ltd.
Tel
13761310616
Fax
QQ: 39324283
Email
39324283@qq.com
Country
China
ProdList
2009
Advantage
58
Heze Development Zone chuangli Chemical Co., Ltd.
Tel
0530-+86-530-529 6766，+86-15666160102 15666160102
Fax
0530-529 6766
Email
info@chuangli-chem.com
Country
China
ProdList
838
Advantage
55
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58

2138299-34-8, diABZI STING agonist-1 trihydrochlorideRelated Search:


  • diABZI STING agonist-1 trihydrochloride
  • diABZI STING agonist-1
  • STING agonist-1（compound 3）trihydrochloride
  • STING?agonist?diABZ
  • (E)-1-(4-(5-Carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-morpholinopropoxy)-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-methoxy-1H-benzimidazole-5-carboxamide tris(hydrochloride)
  • diABZI STING Agonist 3 (hydrochloride)
  • STING agonist-1 trihydrochloride
  • 1-[(2E)-4-[5-(Aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-1H-benzimidazole-5-carboxamide Hydrochloride (1:3)
  • di-ABZI
  • inhibit,diABZI STING agonist1 trihydrochloride,MPYS,diABZI STING agonist-1 trihydrochloride,ERIS,STING,Inhibitor,MITA,Stimulator of Interferon Genes,TMEM173,diABZI STING agonist 1 trihydrochloride
  • diABZI STING Agonist-1 (hydrochloride)
  • diABZI STING agonist-1 3HCl
  • (E)-1-(4-(5-Carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-morpholinopropoxy)-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-methoxy-1H-benzo[d]imidazole-5-carboxamide trihydrochloride
  • 2138299-34-8