diABZI STING agonist-1 trihydrochloride

Product Name: diABZI STING agonist-1 trihydrochloride
CAS No.: 2138299-34-8
Chemical Name: diABZI STING agonist-1 trihydrochloride
Synonyms: di-ABZI;STING?agonist?diABZ;diABZI STING agonist-1;diABZI STING agonist-1 3HCl;STING agonist-1 trihydrochloride;diABZI STING Agonist-1 (hydrochloride);diABZI STING Agonist 3 (hydrochloride);diABZI STING agonist-1 trihydrochloride;STING agonist-1（compound 3）trihydrochloride;inhibit,diABZI STING agonist1 trihydrochloride,MPYS,diABZI STING agonist-1 trihydrochloride,ERIS,STING,Inhibitor,MITA,Stimulator of Interferon Genes,TMEM173,diABZI STING agonist 1 trihydrochloride
CBNumber: CB84818416
Molecular Formula: C42H52ClN13O7
Formula Weight: 886.41
MOL File: 2138299-34-8.mol

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diABZI STING agonist-1 trihydrochloride Property

storage temp.: Store at -20°C
solubility: DMSO: 50 mg/ml
form: A crystalline solid
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28054
Product name: diABZI STING Agonist 3 (hydrochloride)
Packaging: 1mg
Price: $299
Updated: 2024/03/01

Cayman Chemical

Product number: 28054
Product name: diABZI STING Agonist 3 (hydrochloride)
Packaging: 5mg
Price: $743
Updated: 2024/03/01

Cayman Chemical

Product number: 28054
Product name: diABZI STING Agonist 3 (hydrochloride)
Packaging: 500μg
Price: $158
Updated: 2024/03/01

TRC

Product number: A629825
Product name: 1-[(2E)-4-[5-(Aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-1H-benzimidazole-5-carboxamideHydrochloride(1:3)
Packaging: 1mg
Price: $360
Updated: 2021/12/16

AK Scientific

Product number: 1582EN
Product name: 1-[(E)-4-[5-Carbamoyl-2-[(2-ethyl-5-methylpyrazole-3-carbonyl)amino]-7-(3-morpholin-4-ylpropoxy)benzimidazol-1-yl]but-2-enyl]-2-[(2-ethyl-5-methylpyrazole-3-carbonyl)amino]-7-methoxybenzimidazole-5-carboxamide;trihydrochloride
Packaging: 1mg
Price: $430
Updated: 2021/12/16

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diABZI STING agonist-1 trihydrochloride Chemical Properties,Usage,Production

Description

diABZI STING agonist-1 is an agonist of the stimulator of interferon genes (STING) pathway. It induces secretion of IFN-β in human peripheral blood mononuclear cells (PBMCs; EC₅₀ = 130 nM). diABZI STING agonist-1 (2.5 mg/kg) increases serum levels of IFN-β, IL-6, TNF, and KC/GROα in wild-type, but not Sting-/-, mice. It inhibits the cytopathic effect of the common cold human coronavirus 229E (HCoV-229E) in infected MRC-5 cells (EC₅₀ = 3 nM). diABZI STING agonist-1 also decreases the level of severe acute respiratory coronavirus 2 (SARS-CoV-2) RNA in primary human bronchial airway epithelial cells in an air-liquid interface assay. It decreases tumor volume and increases survival in a CT26 murine colorectal cancer model when administered at a dose of 3 mg/kg.

Uses

1-[(2E)-4-[5-(Aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-1H-benzimidazole-5-carboxamide Hydrochloride (1:3), an amino acid derivatve used in preparation of STING protein.

diABZI STING agonist-1 trihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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diABZI STING agonist-1 trihydrochloride Suppliers

China 44 United States 6 Global 50

Nantong QuanYi Biotechnology Co., Ltd

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2138299-34-8, diABZI STING agonist-1 trihydrochlorideRelated Search:

diABZI STING agonist-1 trihydrochloride

diABZI STING agonist-1

STING agonist-1（compound 3）trihydrochloride

STING?agonist?diABZ

(E)-1-(4-(5-Carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-morpholinopropoxy)-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-methoxy-1H-benzimidazole-5-carboxamide tris(hydrochloride)

diABZI STING Agonist 3 (hydrochloride)

STING agonist-1 trihydrochloride

1-[(2E)-4-[5-(Aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-1H-benzimidazole-5-carboxamide Hydrochloride (1:3)

di-ABZI

inhibit,diABZI STING agonist1 trihydrochloride,MPYS,diABZI STING agonist-1 trihydrochloride,ERIS,STING,Inhibitor,MITA,Stimulator of Interferon Genes,TMEM173,diABZI STING agonist 1 trihydrochloride

diABZI STING Agonist-1 (hydrochloride)

diABZI STING agonist-1 3HCl

(E)-1-(4-(5-Carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-morpholinopropoxy)-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-methoxy-1H-benzo[d]imidazole-5-carboxamide trihydrochloride

2138299-34-8