3'-O-MOE-G(iBu)-2'-phosphoramidite
- Product Name
- 3'-O-MOE-G(iBu)-2'-phosphoramidite
- CAS No.
- 256224-06-3
- Chemical Name
- 3'-O-MOE-G(iBu)-2'-phosphoramidite
- Synonyms
- 3’-O-MOE-G(iBu)-2’-phosphor;3'-O-MOE-G(iBu)-2'-phosphoramidite;3’-O-MOE-G(iBu)-2’-phos phoramidite;5’-O-DMTr-N2-iso-butyroyl-3’-O-(2-methoxy ethyl)guanosine-2’-CED-phosphoramidite;Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-, 2'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (9CI)
- CBNumber
- CB84842110
- Molecular Formula
- C47H60N7O10P
- Formula Weight
- 914.01
- MOL File
- 256224-06-3.mol
3'-O-MOE-G(iBu)-2'-phosphoramidite Property
- pka
- 9.16±0.20(Predicted)
- InChIKey
- BWLKVJLYUDLOLH-KEFUZROQNA-N
- SMILES
- C(C1C=CC=CC=1)(C1C=CC(OC)=CC=1)(C1C=CC(OC)=CC=1)OC[C@H]1O[C@@H](N2C=NC3C(NC(NC(=O)C(C)C)=NC2=3)=O)[C@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@H]1OCCOC |&1:25,27,44,59,r|
3'-O-MOE-G(iBu)-2'-phosphoramidite Chemical Properties,Usage,Production
Description
3’-O-MOE-G(iBu)-2’-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)
Chemical Properties
White to off-white powder
Uses
3’-O-MOE-G(iBu)-2’-phosphoramidite is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].
References
[1] Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51. DOI:10.1073/pnas.0631696100
3'-O-MOE-G(iBu)-2'-phosphoramidite Preparation Products And Raw materials
Raw materials
Preparation Products
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