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(S)-BOL-303242X)

Product Name
(S)-BOL-303242X)
CAS No.
887375-15-7
Chemical Name
(S)-BOL-303242X)
Synonyms
(S)-ZK-245186;(S)-Mapracorat;(S)-BOL-303242X);(Synonyms: (S)-ZK-245186;(S)-Mapracorat (Synonyms: (S)-ZK-245186;(SYNONYMS: (S)-ZK-245186; (S)-BOL-303242X);7-Benzofuranpropanol, 5-fluoro-2,3-dihydro-γ,γ-dimethyl-α-[[(2-methyl-5-quinolinyl)amino]methyl]-α-(trifluoromethyl)-, (αS)-
CBNumber
CB84844417
Molecular Formula
C25H26F4N2O2
Formula Weight
462.49
MOL File
887375-15-7.mol
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(S)-BOL-303242X) Property

Boiling point:
602.1±55.0 °C(Predicted)
Density 
1.316±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: ≥ 50.6 mg/mL (109.41 mM)
pka
11.75±0.29(Predicted)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0084839
Product name
(S)-Mapracorat
Purity
99.40%
Packaging
5mg
Price
$650
Updated
2021/12/16
ChemScene
Product number
CS-0084839
Product name
(S)-Mapracorat
Purity
99.40%
Packaging
10mg
Price
$950
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573271
Product name
(S)-Mapracorat
Purity
>98%
Packaging
100mg
Price
$1802
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573271
Product name
(S)-Mapracorat
Purity
>98%
Packaging
250mg
Price
$3580.2
Updated
2021/12/16
DC Chemicals
Product number
DC20017
Product name
(S)-Mapracorat
Purity
>98%
Packaging
250mg
Price
$2400
Updated
2021/12/16
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(S)-BOL-303242X) Chemical Properties,Usage,Production

Description

(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist.

(S)-Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC50 value of approximately 0.2 nM.

Intradermal injection of compound 48/80 (50 μg in 50 μL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with (S)-Mapracorat (0.1%) leads to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas.

References

[1]. BÄumer W , et al. The selective glucocorticoid receptor agonist mapracorat displays a favourable safety-efficacy ratio for the topical treatment of inflammatory skin diseases in dogs. Vet Dermatol. 2017 Feb; 28(1):46-e11.

(S)-BOL-303242X) Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-BOL-303242X) Suppliers

China 7 United States 1 Global 8
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
Changzhou Xuanye Technology Co., Ltd
Tel
15195022192
Email
279776773@qq.com
Country
China
ProdList
2003
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11217
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
029-81145920 13259709322
Fax
029-88380327
Email
1027@dideu.com
Country
China
ProdList
10009
Advantage
58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd
Tel
021-59167510 18117107507
Email
vip@med-life.cn
Country
China
ProdList
4997
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58

887375-15-7, (S)-BOL-303242X)Related Search:


  • (S)-BOL-303242X)
  • (S)-Mapracorat (Synonyms: (S)-ZK-245186
  • (Synonyms: (S)-ZK-245186
  • (SYNONYMS: (S)-ZK-245186; (S)-BOL-303242X)
  • (S)-Mapracorat
  • (S)-ZK-245186
  • 7-Benzofuranpropanol, 5-fluoro-2,3-dihydro-γ,γ-dimethyl-α-[[(2-methyl-5-quinolinyl)amino]methyl]-α-(trifluoromethyl)-, (αS)-
  • 887375-15-7
  • C25H26F4N2O2