ASP-2905)
- Product Name
- ASP-2905)
- CAS No.
- 792184-90-8
- Chemical Name
- ASP-2905)
- Synonyms
- ASP-2905);ASP 2905 (ASP2905;ASP2905, 10 mM in DMSO;N2-(4-Fluorophenyl)-N4-phenyl-N6-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine;1,3,5-Triazine-2,4,6-triamine, N2-(4-fluorophenyl)-N4-phenyl-N6-(2-pyrimidinylmethyl)-;Kv12.2,KcsA,Inhibitor,ASP2905,ASP 2905,cognitive,Kcnh3,CNS,Potassium Channel,inhibit,antipsychotic
- CBNumber
- CB84844482
- Molecular Formula
- C20H17FN8
- Formula Weight
- 388.4
- MOL File
- 792184-90-8.mol
ASP-2905) Property
- Boiling point:
- 600.5±65.0 °C(Predicted)
- Density
- 1.427±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: Soluble: =10 mg/ml
- form
- Solid
- pka
- 3.27±0.10(Predicted)
- color
- White to off-white
ASP-2905) Chemical Properties,Usage,Production
Description
ASP2905 hydrochloride is a potent and selective inhibitor of the potassium voltage-gated channel subfamily H member 3 (KCNH3).
Uses
ASP2905 is a potent and selective potassium channel Kv12.2 inhibitor encoded by the Kcnh3/BEC1 gene. ASP2905 can cross the blood-brain barrier and has antipsychotic activities[1][2].
in vivo
ASP2905 treatment inhibits hyperlocomotion induced by Phencyclidine. And significantly ameliorates Phencyclidine-induced prolongation of immobility time in mice subjected to the forced swimming test[2].
| Animal Model: | Male ddY mice (aged 4-5 weeks) injected with Phencyclidine hydrochloride (PCP)[2] |
| Dosage: | 0.01 mg/kg, 0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg |
| Administration: | Oral administration; once |
| Result: | Inhibited hyperlocomotion induced by Phencyclidine. |
References
[1] Shinji Takahashi, et al. Neurochemical and neuropharmacological characterization of ASP2905, a novel potent selective inhibitor of the potassium channel KCNH3. Eur J Pharmacol. 2017 Sep 5;810:26-35. DOI:10.1016/j.ejphar.2017.05.045
[2] Shinji Takahashi, et al. ASP2905, a specific inhibitor of the potassium channel Kv12.2 encoded by the Kcnh3 gene, is psychoactive in mice. Behav Brain Res. 2020 Jan 27;378:112315. DOI:10.1016/j.bbr.2019.112315
[3] SHINJI TAKAHASHI. The KCNH3 inhibitor ASP2905 shows potential in the treatment of attention deficit/hyperactivity disorder.[J]. PLoS ONE, 2018: e0207750. DOI: 10.1371/journal.pone.0207750
ASP-2905) Preparation Products And Raw materials
Raw materials
Preparation Products
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