ChemicalBook > CAS DataBase List > diABZI STING agonist-1 Tautomerism

diABZI STING agonist-1 Tautomerism

Product Name: diABZI STING agonist-1 Tautomerism
CAS No.: 2138498-18-5
Chemical Name: diABZI STING agonist-1 Tautomerism
Synonyms: Tautomerism;diABZI STING agonist (Compound 3);diABZI STING agonist-1 Tautomerism;diABZI STING agonist 1 (compound 3);diABZI STING agonist (Compound 3) ，S8796;(E)-1-((E)-4-((E)-5-Carbamoyl-2-((1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)imino)-7-(3-morpholinopropoxy)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-2-((1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)imino)-7-methoxy-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamide;1H-Benzimidazole-5-carboxamide, 1-[(2E)-4-[(2E)-5-(aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]imino]-2,3-dihydro-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]imino]-2,3-dihydro-7-[3-(4-morpholinyl)propoxy]-, (2E)-
CBNumber: CB84844710
Molecular Formula: C42H51N13O7
Formula Weight: 849.94
MOL File: 2138498-18-5.mol

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diABZI STING agonist-1 Tautomerism Property

Density: 1.44±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Solid
pka: 11.87±0.43(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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diABZI STING agonist-1 Tautomerism Chemical Properties,Usage,Production

Chemical Properties

diABZI STING agonist-1 Tautomerism is a potent non-nucleoside STING agonist with great potential for the treatment of human cancers.

Uses

diABZI STING agonist-1 tautomerism is a tautomerism of diABZI STING agonist-1 (HY-112921) (compound 3). diABZI STING agonist-1 tautomerism is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively[1].

in vitro

diABZI STING agonist-1 (Tautomerism) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. At a concentration of 1 μM, it demonstrates high selectivity against more than 350 kinases tested.

in vivo

diABZI STING agonist-1 (Tautomerism) (subcutaneous injection; 2.5 mg/kg) induces STING-dependent activation of type-I interferon and pro-inflammatory cytokines in vivo.

References

[1] Ramanjulu JM, et al. Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature. 2018 Nov 7. DOI:10.1038/s41586-018-0705-y

diABZI STING agonist-1 Tautomerism Preparation Products And Raw materials

Raw materials

Preparation Products

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2138498-18-5, diABZI STING agonist-1 TautomerismRelated Search:

diABZI STING agonist-1 Tautomerism

1H-Benzimidazole-5-carboxamide, 1-[(2E)-4-[(2E)-5-(aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]imino]-2,3-dihydro-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]imino]-2,3-dihydro-7-[3-(4-morpholinyl)propoxy]-, (2E)-

diABZI STING agonist 1 (compound 3)

diABZI STING agonist (Compound 3)

Tautomerism

(E)-1-((E)-4-((E)-5-Carbamoyl-2-((1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)imino)-7-(3-morpholinopropoxy)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-2-((1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)imino)-7-methoxy-2,3-dihydro-1H-benzo[d]imidazole-5-carboxamide

diABZI STING agonist (Compound 3) ，S8796

2138498-18-5