GT 949

Product Name: GT 949
CAS No.: 460330-27-2
Chemical Name: GT 949
Synonyms: GT 949;GT 949, 10 mM in DMSO;3-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one;2(1H)-Quinolinone, 3-[(4-cyclohexyl-1-piperazinyl)[1-(2-phenylethyl)-1H-tetrazol-5-yl]methyl]-6-methoxy-
CBNumber: CB84844846
Molecular Formula: C30H37N7O2
Formula Weight: 527.66
MOL File: 460330-27-2.mol

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GT 949 Property

Boiling point:: 770.7±60.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 100 mM; Ethanol: 10 mM, heated
form: A solid
pka: 10.55±0.70(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2823
Product name: GT949
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $78.18
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2823
Product name: GT949
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $268
Updated: 2025/07/31

Tocris

Product number: 6578
Product name: GT949
Purity: ≥98%(HPLC)
Packaging: 10
Price: $195
Updated: 2021/12/16

Tocris

Product number: 6578
Product name: GT949
Purity: ≥98%(HPLC)
Packaging: 50
Price: $806
Updated: 2021/12/16

TRC

Product number: G800510
Product name: GT949
Packaging: 2.5mg
Price: $200
Updated: 2021/12/16

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GT 949 Chemical Properties,Usage,Production

Uses

GT 949 is a selective EAAT2 positive allosteric modulator (EC50 = 0.26 nM). Enhances the glutamate translocation rate, with no effect on substrate interaction. Increases glutamate removal by 70%. Exhibits no effect on DAT, SERT and NET or NMDA receptors.

Biological Activity

GT949 is a potent and selective positive allosteric modulator (PAM) of the excitatory amino acid transporter EAAT2 (glutamate uptake EC50 = 0.26 nM; COS-7 EAAT2 transfectant), but not EAAT1 or EAAT3. GT949 enhances glutamate uptake of cultured r at astrocytes (EC50 = 1 nM, Emax = 158%) with no potency toward human serotonin (SERT), noradrenaline (NET) and dopamine (DAT) transporters, nor NMDA receptors (murine primary cortical neurons).

IC 50

EAAT2

storage

Store at -20°C

GT 949 Preparation Products And Raw materials

Raw materials

Preparation Products

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GT 949 Suppliers

China 29 United Kingdom 1 United States 5 Global 35

ShangHai Caerulum Pharma Discovery Co., Ltd.

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BOC Sciences

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Shanghai EFE Biological Technology Co., Ltd.

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Shanghai YuanYe Biotechnology Co., Ltd.

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Tianjin Kailiqi Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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ShangHai ChuanQian Chemcial Technique Centre

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Wuhan Topule

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Jinan Jiuli Biotechnology Co. , Ltd.

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460330-27-2, GT 949Related Search:

GT 949

3-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one

2(1H)-Quinolinone, 3-[(4-cyclohexyl-1-piperazinyl)[1-(2-phenylethyl)-1H-tetrazol-5-yl]methyl]-6-methoxy-

GT 949, 10 mM in DMSO

460330-27-2