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TM-25659

Product Name
TM-25659
CAS No.
260553-97-7
Chemical Name
TM-25659
Synonyms
TM-25659;TM 25659,TM25659;TM-25659, 10 mM in DMSO;TAZ Activity Modulator, TM-25659;3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-5-methyl-6-(pyridin-3-yl)-3H-imidazo[4,5-b]pyridine;3H-Imidazo[4,5-b]pyridine, 2-butyl-5-methyl-6-(3-pyridinyl)-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
CBNumber
CB84845065
Molecular Formula
C30H28N8
Formula Weight
500.6
MOL File
260553-97-7.mol
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TM-25659 Property

Boiling point:
768.0±70.0 °C(Predicted)
Density 
1.29±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 135 mg/mL (269.68 mM);Water : < 0.1 mg/mL (insoluble)
form 
Solid
pka
4.15±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd
Product number
orb573303
Product name
TM-25659
Purity
>98%
Packaging
100mg
Price
$1949.9
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573303
Product name
TM-25659
Purity
>98%
Packaging
250mg
Price
$3876
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573303
Product name
TM-25659
Purity
>98%
Packaging
1g
Price
$7729.9
Updated
2021/12/16
Ambeed
Product number
A981573
Product name
TM-25659
Purity
98%
Packaging
1mg
Price
$56
Updated
2021/12/16
Ambeed
Product number
A981573
Product name
TM-25659
Purity
98%
Packaging
5mg
Price
$112
Updated
2021/12/16
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TM-25659 Chemical Properties,Usage,Production

Uses

TM 25659 is a novel TAZ modulator that inhibited viability in Madin-Darby dog kidney cell and in human colorectal adenocarcinoma cell.

Biological Activity

Cell permeable: yes

in vivo

TM-25659 (50 mg/kg, i.p., every other day for 2 weeks) suppresses bone loss in vivo and decreases weight gain in an obesity model[1].

TM-25659 has a favourable pharmacokinetic profile in rats. The plasma concentration of TM-25659 declines with an approximate t1/2 of 7 or 10 h following i.v or p.o. administration respectively. The systemic clearance (CL) is 0.21 L×h-1×kg-1 and the volume of distribution at steady-state (1.91 L×h-1×kg-1) is larger than the volume of total body fluids[1].

Animal Model:C57BL6 mice (4- to 6-week-old )[1]
Dosage:50 mg/kg
Administration:I.p., every other day for 2 weeks
Result:Attenuated weight gain in these obese mice[1].
Animal Model:Adult male Sprague-Dawley rats[1]
Dosage:10 mg/kg
Administration:I.v. (2, 10 and 30 min), oral (15 and 30 min, and 1, 2, 4 and 8 h)
Result:Oral administration for 4 weeks moderately but significantly attenuated weight gain and partly restored BMD in the OVX rats[1].

TM-25659 Preparation Products And Raw materials

Raw materials

Preparation Products

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TM-25659 Suppliers

China 20 India 1 United States 3 Global 24
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD
Tel
13816107857
Fax
qq: 276312098
Email
sales@fortunechem-sh.com
Country
China
ProdList
984
Advantage
58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3934
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58

260553-97-7, TM-25659Related Search:


  • TM-25659
  • 3H-Imidazo[4,5-b]pyridine, 2-butyl-5-methyl-6-(3-pyridinyl)-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
  • TM 25659,TM25659
  • 3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-5-methyl-6-(pyridin-3-yl)-3H-imidazo[4,5-b]pyridine
  • TM-25659, 10 mM in DMSO
  • TAZ Activity Modulator, TM-25659
  • 260553-97-7
  • C30H28N8