ChemicalBook > CAS DataBase List > (S,R,S)-AHPC-PEG3-Alkyne
(S,R,S)-AHPC-PEG3-Alkyne
- Product Name
- (S,R,S)-AHPC-PEG3-Alkyne
- CAS No.
- 2374122-30-0
- Chemical Name
- (S,R,S)-AHPC-PEG3-Alkyne
- Synonyms
- (S,R,S)-AHPC-PEG3-Alkyne;(S,R,S)-AHPC-PEG?-Alkyne;(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-[(2S)-3,3-dimethyl-2-(3-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}propanamido)butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
- CBNumber
- CB84846305
- Molecular Formula
- C32H44N4O7S
- Formula Weight
- 628.79
- MOL File
- 2374122-30-0.mol
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(S,R,S)-AHPC-PEG3-Alkyne Property
- Boiling point:
- 881.7±65.0 °C(Predicted)
- Density
- 1.224±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 14.07±0.40(Predicted)
- form
- powder or crystals
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 901533
- Product name
- (S,R,S)-AHPC-PEG3-Alkyne
- Purity
- ≥95%
- Packaging
- 50MG
- Price
- $632
- Updated
- 2023/06/20
Iris Biotech GmbH
- Product number
- PTC1480
- Product name
- (S,R,S)-AHPC-PEG3-Alkyne
- Packaging
- 50mg
- Price
- $648
- Updated
- 2021/12/16
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(S,R,S)-AHPC-PEG3-Alkyne Chemical Properties,Usage,Production
Uses
Protein degrader builiding block (S,R,S)-AHPC-PEG4-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
reaction suitability
reaction type: click chemistry
reagent type: ligand-linker conjugate
(S,R,S)-AHPC-PEG3-Alkyne Preparation Products And Raw materials
Raw materials
Preparation Products
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(S,R,S)-AHPC-PEG3-Alkyne Suppliers
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
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- sales@aladdinsci.com
- Country
- United States
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View Lastest Price from (S,R,S)-AHPC-PEG3-Alkyne manufacturers
Xian confluore Biological Technology Co., Ltd.
- Product
- (S,R,S)-AHPC-PEG3-Alkyne 2374122-30-0
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- >99.00%
- Supply Ability
- 100mg
- Release date
- 2024-04-01