(S,R,S)-AHPC-PEG3-Alkyne

Product Name: (S,R,S)-AHPC-PEG3-Alkyne
CAS No.: 2374122-30-0
Chemical Name: (S,R,S)-AHPC-PEG3-Alkyne
Synonyms: (S,R,S)-AHPC-PEG3-Alkyne;(S,R,S)-AHPC-PEG?-Alkyne;(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-[(2S)-3,3-dimethyl-2-(3-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}propanamido)butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
CBNumber: CB84846305
Molecular Formula: C32H44N4O7S
Formula Weight: 628.79
MOL File: 2374122-30-0.mol

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(S,R,S)-AHPC-PEG3-Alkyne Property

Boiling point:: 881.7±65.0 °C(Predicted)
Density: 1.224±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.07±0.40(Predicted)
form: powder or crystals

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 901533
Product name: (S,R,S)-AHPC-PEG3-Alkyne
Purity: ≥95%
Packaging: 50MG
Price: $632
Updated: 2023/06/20

Iris Biotech GmbH

Product number: PTC1480
Product name: (S,R,S)-AHPC-PEG3-Alkyne
Packaging: 50mg
Price: $648
Updated: 2021/12/16

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(S,R,S)-AHPC-PEG3-Alkyne Chemical Properties,Usage,Production

Uses

Protein degrader builiding block (S,R,S)-AHPC-PEG4-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

reaction suitability

reaction type: click chemistry
reagent type: ligand-linker conjugate

(S,R,S)-AHPC-PEG3-Alkyne Preparation Products And Raw materials

Raw materials

Preparation Products

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(S,R,S)-AHPC-PEG3-Alkyne Suppliers

China 10 India 1 United States 1 Global 12

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52924
Advantage: 58

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View Lastest Price from (S,R,S)-AHPC-PEG3-Alkyne manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: (S,R,S)-AHPC-PEG3-Alkyne 2374122-30-0
Price: US $0.00/mg
Min. Order: 100mg
Purity: >99.00%
Supply Ability: 100mg
Release date: 2024-04-01

2374122-30-0, (S,R,S)-AHPC-PEG3-AlkyneRelated Search:

(S,R,S)-AHPC-PEG3-Alkyne

(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker–E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate

(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

(S,R,S)-AHPC-PEG?-Alkyne

(2S,4R)-1-[(2S)-3,3-dimethyl-2-(3-{2-[2-(prop-2-yn-1-yloxy)ethoxy]ethoxy}propanamido)butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide

2374122-30-0