Rabacfosadine succinate
- Product Name
- Rabacfosadine succinate
- CAS No.
- 1431856-99-3
- Chemical Name
- Rabacfosadine succinate
- Synonyms
- GS-9219-01;GS-9219 succinate;VDC-1101 succinate;Rabacfosadine succinate;VDC 1101 succinate VDC1101 succinate;ethyl (2S)-2-[[2-[2-amino-6-(cyclopropylamino)purin-9-yl]ethoxymethyl-[[(2S)-1-ethoxy-1-oxopropan-2-yl]amino]phosphoryl]amino]propanoate
- CBNumber
- CB84848253
- Molecular Formula
- C25H41N8O10P
- Formula Weight
- 644.62
- MOL File
- 1431856-99-3.mol
Rabacfosadine succinate Property
- InChI
- InChI=1/C21H35N8O6P.C4H6O4/c1-5-34-19(30)13(3)27-36(32,28-14(4)20(31)35-6-2)12-33-10-9-29-11-23-16-17(24-15-7-8-15)25-21(22)26-18(16)29;5-3(6)1-2-4(7)8/h11,13-15H,5-10,12H2,1-4H3,(H2,27,28,32)(H3,22,24,25,26);1-2H2,(H,5,6)(H,7,8)/t13-,14-;/s3
- InChIKey
- XLBDQSJWTNREFA-FGVWXQOBNA-N
- SMILES
- C(C(=O)O)CC(=O)O.C(N1C=NC2=C(N=C(N)N=C12)NC1CC1)COCP(=O)(N[C@@H](C)C(=O)OCC)N[C@@H](C)C(=O)OCC |&1:29,37,r|
Rabacfosadine succinate Chemical Properties,Usage,Production
Description
Rabacfosadine succinate, also known as VDC-1101 or GS-9219, is a double prodrug of the nucleotide analogue 9-(2-phosphonylmethoxyethl)guanine (PMEG). It is a novel chemotherapy drug approved for the treatment of lymphoma in dogs. Rabacfosadine administered every 3 weeks is usually well tolerated and has shown significant anti-tumour activity in dogs with previously untreated medium and large cell lymphoma.
Uses
Rabacfosadine succinate is used as the acyclic nucleoside phosphonate PMEG double prodrug.
Mechanism of action
Rabacfosadine succinate targets lymphocytes and acts as an anti-tumour agent by inhibiting DNA synthesis through the inhibition of DNA polymerase.
Side effects
The most common adverse reaction to Rabacfosadine succinate is gastrointestinal (anorexia/diarrhoea), which is generally resolved by supportive therapy and/or dose adjustment. Three dogs developed VCOG-CTCAE grade 5 delayed pulmonary fibrosis.
Rabacfosadine succinate Preparation Products And Raw materials
Raw materials
Preparation Products
Rabacfosadine succinate Suppliers
- Tel
- 15002134094
- marketing@targetmol.cn
- Country
- China
- ProdList
- 19704
- Advantage
- 58
- Tel
- +8613340353813
- info@hanpets.com
- Country
- China
- ProdList
- 26
- Advantage
- 58
View Lastest Price from Rabacfosadine succinate manufacturers
- Product
- Rabacfosadine Succinate 1431856-99-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 tons
- Release date
- 2023-03-21