1-BROMO-3,4-DIMETHOXY-2-METHYLBENZENE
- Product Name
- 1-BROMO-3,4-DIMETHOXY-2-METHYLBENZENE
- CAS No.
- 74866-17-4
- Chemical Name
- 1-BROMO-3,4-DIMETHOXY-2-METHYLBENZENE
- Synonyms
- 6-Bromo-2,3-dimethoxytoluene;1-BROMO-3,4-DIMETHOXY-2-METHYLBENZENE;Benzene, 1-bromo-3,4-dimethoxy-2-methyl-
- CBNumber
- CB8485319
- Molecular Formula
- C9H11BrO2
- Formula Weight
- 231.09
- MOL File
- 74866-17-4.mol
1-BROMO-3,4-DIMETHOXY-2-METHYLBENZENE Property
- Melting point:
- 59-60 °C(Solv: methanol (67-56-1))
- Boiling point:
- 252.9±35.0 °C(Predicted)
- Density
- 1.360±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- Solid
- color
- White Crystalline
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B619395
- Product name
- 4-Bromo-3-methylveratrole
- Packaging
- 250mg
- Price
- $385
- Updated
- 2021/12/16
- Product number
- CS-M3412
- Product name
- 1-Bromo-3,4-dimethoxy-2-methylbenzene
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 1639AC
- Product name
- 1-Bromo-3,4-dimethoxy-2-methylbenzene
- Packaging
- 1g
- Price
- $304
- Updated
- 2021/12/16
- Product number
- HCH0063402
- Product name
- 1-BROMO-3,4-DIMETHOXY-2-METHYLBENZENE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.76
- Updated
- 2021/12/16
- Product number
- CS-M3412
- Product name
- 1-Bromo-3,4-dimethoxy-2-methylbenzene
- Packaging
- 5g
- Price
- $700
- Updated
- 2021/12/16
1-BROMO-3,4-DIMETHOXY-2-METHYLBENZENE Chemical Properties,Usage,Production
Uses
4-Bromo-3-methylveratrole is an intermediate in the synthesis of carbazomycin A (C175830), is used in biological studies for antimalarial and antituberculosis activity which are isolated from Streptomyces.
Synthesis
4463-33-6
74866-17-4
General procedure for the synthesis of 1-bromo-3,4-dimethoxy-2-methylbenzene from 2,3-dimethoxytoluene: To a solution of 2,3-dimethoxytoluene (55 g, 361.8 mmol) in acetonitrile (ACN, 1.8 L) was added N-bromosuccinimide (NBS, 65.3 g, 369 mmol) in batches, and the reaction was stirred under nitrogen protection at room temperature. The mixture was stirred for 24 hours at room temperature under nitrogen protection. After completion of the reaction, the reaction mixture was diluted with ethyl acetate, washed sequentially with saturated aqueous sodium bicarbonate (NaHCO3) and water, and the organic phase was dried with anhydrous sodium sulfate (Na2SO4). The solvent was concentrated under reduced pressure and the resulting crude product was recrystallized from methanol (MeOH) to give pure 1-bromo-3,4-dimethoxy-2-methylbenzene as a white solid (67 g, 80% yield). The structure of the product was analyzed by 1H NMR (CDCl3, 400 MHz) δ7.22 (d, J = 8.8 Hz, 1H), 6.64 (d, J = 8.8 Hz, 1H), 3.82 (s, 3H), 3.76 (s, 3H), 2.32 (s, 3H) and 13C NMR (CDCl3, 100 MHz): δ152.1, 148.0, 132.2, 127.2, 116.0, 110.9, 60.3, 55.8, 16.0 confirmed; GC-MS showed molecular ion peak m/z 230 [M+] as expected.
References
[1] Patent: WO2006/83417, 2006, A2. Location in patent: Example 5
[2] Synlett, 2011, # 18, p. 2663 - 2666
[3] Tetrahedron Letters, 2000, vol. 41, # 8, p. 1171 - 1174
[4] Heterocycles, 2007, vol. 74, # C, p. 895 - 912
[5] Tetrahedron Letters, 1997, vol. 38, # 9, p. 1535 - 1538
1-BROMO-3,4-DIMETHOXY-2-METHYLBENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-BROMO-3,4-DIMETHOXY-2-METHYLBENZENE manufacturers
- Product
- 1-BROMO-3,4-DIMETHOXY-2-METHYLBENZENE 74866-17-4
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-08