ROSEOFLAVIN

Product Name: ROSEOFLAVIN
CAS No.: 51093-55-1
Chemical Name: ROSEOFLAVIN
Synonyms: ROSEOFLAVIN;8-Demethyl-8-(dimethylamino)riboflavin;8-demethyl-8-(dimethylamino)-riboflavi;8-DiMethylaMinoriboflavin, Roseoflavine;Riboflavin, 8-demethyl-8-(dimethylamino)-;8-(Dimethylamino)-7-methyl-10-((2S,3S,4R)-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione;pigment,bacteria,resistant,Inhibitor,RNA,riboswitch,ligand,analog,antimicrobial,Bacterial,Roseoflavin,inhibit
CBNumber: CB8485793
Molecular Formula: C18H23N5O6
Formula Weight: 405.41
MOL File: 51093-55-1.mol

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ROSEOFLAVIN Property

Melting point:: 276-278°C
Density: 1.59±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
pka: 9.69±0.70(Predicted)
form: powder
color: white to very dark brown
Stability:: Light sensitive

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1583
Product name: Roseoflavin
Purity: ≥95% (HPLC)
Packaging: 5MG
Price: $105
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1583
Product name: Roseoflavin
Purity: ≥95% (HPLC)
Packaging: 25MG
Price: $359
Updated: 2023/06/20

Cayman Chemical

Product number: 16001
Product name: Roseoflavin
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 16001
Product name: Roseoflavin
Purity: ≥95%
Packaging: 5mg
Price: $55
Updated: 2024/03/01

Cayman Chemical

Product number: 16001
Product name: Roseoflavin
Purity: ≥95%
Packaging: 10mg
Price: $84
Updated: 2024/03/01

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ROSEOFLAVIN Chemical Properties,Usage,Production

Chemical Properties

Dark Reddish/Brown Crystalline Solid

Uses

Has weak antibacterial activity against some gram-positive bacteria, especially Staphylococcus aureus, Sarcina latea, Bacillus cereus, and Bacillus subtilis. Also exhibits antiriboflavin activity and inhibits the biosynthesis of riboflavin by a r

Uses

An analog known to compete with Riboflavin in Lactobacillus casei. Riboflavin kinase substrate and inhibitor

Uses

Roseoflavin is an antibacterial pigment isolated from Streptomyces davawensis as an anti-metabolite of riboflavin. Roseoflavin is used as a substrate to mimic riboflavin in flavin biosynthesis, but leading to the formation of inactive flavin co-factors. More recently, roseoflavin has been shown to be an important regulator of bacterial gene expression by binding to untranslated regions of RNA, so-called ribo-switching sites.

Definition

ChEBI: A benzopteridine that is riboflavin in which the methyl group at position 8 is substituted by a dimethylamino group.

Biochem/physiol Actions

Roseoflavin is an analog of flavin mononucleotide (FMN) and riboflavin with antimicrobial activity. Roseoflavin is converted to the flavin mononucleotide (FMN) analog roseoflavin mononucleotide (RoFMN) by flavokinase and to the flavin adenine dinucleotide (FAD) analog roseoflavin adenine dinucleotide (RoFAD) by FAD synthetase, and acts as a riboflavin antagonist. Roseoflavin is an inhibitor of bacterial riboflavin riboswitches, cis regulatory elements present in non-coding RNA that specifically bind to natural ligands to regulate gene expression. Roseoflavin, converted to RoFMN, blocks the flavin mononucleotide riboswitch-mediated expression of the ribB gene, which is required for riboflavin biosynthesis.

ROSEOFLAVIN Preparation Products And Raw materials

Raw materials

Preparation Products

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ROSEOFLAVIN Suppliers

Canada 1 China 27 Germany 1 India 1 United Kingdom 5 United States 8 Global 43

J & K SCIENTIFIC LTD.

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Sigma-Aldrich

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Shanghai Hongye Biotechnology Co. Ltd

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Shenzhen Polymeri Biochemical Technology Co., Ltd.

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51093-55-1, ROSEOFLAVINRelated Search:

Riboflavin 4,6-DIAMINO-1,3-M-XYLENE ROSEOFLAVIN 1-(2-Metilcrotonil)urea [Italian] N-ALLYL-BENZENE-1,3-DIAMINE N1,N1,6-trimethylbenzene-1,3-diamine

8-Demethyl-8-(dimethylamino)riboflavin

8-DiMethylaMinoriboflavin, Roseoflavine

8-demethyl-8-(dimethylamino)-riboflavi

ROSEOFLAVIN

Riboflavin, 8-demethyl-8-(dimethylamino)-

8-(Dimethylamino)-7-methyl-10-((2S,3S,4R)-2,3,4,5-tetrahydroxypentyl)benzo[g]pteridine-2,4(3H,10H)-dione

pigment,bacteria,resistant,Inhibitor,RNA,riboswitch,ligand,analog,antimicrobial,Bacterial,Roseoflavin,inhibit

51093-55-1

C18H23N5O6

Amines

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Inhibitors