ChemicalBook > CAS DataBase List > V-9302

V-9302

Product Name
V-9302
CAS No.
1855871-76-9
Chemical Name
V-9302
Synonyms
V-9302;V-9302 HCL;V-9302 ，S8818;V-9302 1855871-76-9;V-9302; V9302; V 9302;(S)-2-Amino-4-(bis(2-((3-methylbenzyl)oxy)benzyl)amino)butanoic acid;Butanoic acid, 2-amino-4-[bis[[2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]-, (2S)-;proliferation,stress,mice,flux,uptake,transporter,athymic,Inhibitor,V 9302,V9302,glutamine,nude,inhibit,V-9302,oxidative,HEK-293
CBNumber
CB84868299
Molecular Formula
C34H38N2O4
Formula Weight
538.68
MOL File
1855871-76-9.mol
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V-9302 Property

Boiling point:
688.7±55.0 °C(Predicted)
Density 
1.179±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:85.0(Max Conc. mg/mL);157.79(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.61(Max Conc. mM)
DMF:25.0(Max Conc. mg/mL);46.41(Max Conc. mM)
Ethanol:60.0(Max Conc. mg/mL);111.38(Max Conc. mM)
Water:50.5(Max Conc. mg/mL);93.75(Max Conc. mM)
form 
A crystalline solid
pka
2.08±0.10(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27688
Product name
V-9302
Packaging
1mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
27688
Product name
V-9302
Packaging
25mg
Price
$593
Updated
2024/03/01
Cayman Chemical
Product number
27688
Product name
V-9302
Packaging
5mg
Price
$190
Updated
2024/03/01
Cayman Chemical
Product number
27688
Product name
V-9302
Packaging
10mg
Price
$310
Updated
2024/03/01
AK Scientific
Product number
5403EJ
Product name
(2S)-2-Amino-4-[bis[[2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]butanoicacid
Packaging
10mg
Price
$442
Updated
2021/12/16
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V-9302 Chemical Properties,Usage,Production

Uses

V-9302 is a competitive antagonist of transmembrane glutamine flux. V-9302 selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) not ASCT1. V-9302 inhibits ASCT2-mediated glutamine uptake (IC50=9.6 μM) in HEK-293 cells[1].

Biological Activity

V-9302 is a selective competitive antagonist of the amino acid transporter ASCT2 (SLC1A5) with anti-tumor activity. V-9302 caused reduced cellular viability and increased cell death in a panel of cancer cell lines and reduced tumor cell growth in both HCT-116 and HT29 (Fig. 5f) xenograft models.

in vivo

V-9302 (75 mg/kg; i.p.; daily fo 21 days) prevents tumor growth in both HCT-116 and HT29 xenograft models[1].
The combination of CB-839 and V-9302 (30 mg/kg; i.p.; SNU398 and MHCC97H cells were grown as tumor xenografts in BALB/c nude mice; for 20 or 15 d, respectively) elicits a strong growth inhibition in both SNU398 and MHCC97H xenograft models, while single-drug treatment showed modest anti-tumor effects[2].
V-9302 (50 mg/kg ; i.p.; daily for 5 days) displays markedly reduced tumor growth[3].

Animal Model:6-week old, female athymic nude mice (bearing HCT-116 (KRAS G13D) or HT29 (BRAF V600E) cell-line)[1]
Dosage:75 mg/kg
Administration:Intraperitoneally; daily fo 21 days
Result:Prevented tumor growth.

IC 50

ASCT2

References

[1] Schulte ML, et al. Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacyin preclinical models. Nat Med. 2018 Feb;24(2):194-202. DOI:10.1038/nm.4464
[2] Jin H, et al. A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer. Elife. 2020;9:e56749. Published 2020 Oct 5. DOI:10.7554/eLife.56749
[3] Edwards DN, et al. Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer. J Clin Invest. 2021;131(4):e140100. DOI:10.1172/JCI140100

V-9302 Preparation Products And Raw materials

Raw materials

Preparation Products

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V-9302 Suppliers

China 77 United States 8 Global 85
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4747
Advantage
58
Shanghai Jiyi Biological Technology Co., LTD
Tel
021-54135696 18516235431
Fax
50815371
Email
shgegenetech@163.com
Country
China
ProdList
469
Advantage
55
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9637
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15873
Advantage
55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghaizehan biopharma technology co., Ltd.
Tel
021-61350663 13052117465
Fax
021-61350662
Email
sales@zehanbiopharma.com
Country
China
ProdList
984
Advantage
55
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62

1855871-76-9, V-9302Related Search:


  • V-9302 HCL
  • V-9302
  • V-9302; V9302; V 9302
  • Butanoic acid, 2-amino-4-[bis[[2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]-, (2S)-
  • V-9302 1855871-76-9
  • proliferation,stress,mice,flux,uptake,transporter,athymic,Inhibitor,V 9302,V9302,glutamine,nude,inhibit,V-9302,oxidative,HEK-293
  • (S)-2-Amino-4-(bis(2-((3-methylbenzyl)oxy)benzyl)amino)butanoic acid
  • V-9302 ，S8818
  • 1855871-76-9