5-[(4S)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile Property

Boiling point:

623.9±55.0 °C(Predicted)

Density 

1.42±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO:45.02(Max Conc. mg/mL);112.45(Max Conc. mM)

form 

Solid

pka

9.35±0.70(Predicted)

color 

Light yellow to yellow

optical activity

[α]/D -21 to -29°, c =0.5 in methanol

Hazard and Precautionary Statements (GHS)

5-[(4S)-5-Acetyl-1,2,3,4-tetrahydro-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-4-pyrimidinyl]-2-pyridinecarbonitrile Chemical Properties,Usage,Production

Biological Activity

BAY-677 is the negative control probe for BAY-678, which is a human neutrophil elastase (HNE) inhibitor with >2,000-fold selectivity for HNE over a panel of 21 other serine proteases. For characterization details of BAY-678 and BAY-677, please visit the BAY-677 probe summary on the Structural Genomics Consortium (SGC) website.

BAY-678, the active HNE probe, is available from Sigma. To learn more about and purchase BAY-678, click here.

To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc

storage

Store at -20°C